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| 融点 | 148-151 °C | | 沸点 | 426.1±35.0 °C(Predicted) | | 比重(密度) | 1.180±0.06 g/cm3(Predicted) | | 貯蔵温度 | Sealed in dry,Room Temperature | | 溶解性 | DMSO: 50 mg/mL (210.75 mM) | | 外見 | A solid | | 酸解離定数(Pka) | 14.12±0.70(Predicted) | | Merck | 13,3781 | | InChI | InChI=1S/C12H15NO4/c1-4-17-11-7-9(13-8(2)14)5-6-10(11)12(15)16-3/h5-7H,4H2,1-3H3,(H,13,14) | | InChIKey | GOVWOKSKFSBNGD-UHFFFAOYSA-N | | SMILES | C(OC)(=O)C1=CC=C(NC(C)=O)C=C1OCC | | CAS データベース | 59-06-3(CAS DataBase Reference) | | EPAの化学物質情報 | Ethopabate (59-06-3) |
| 主な危険性 | Xn | | Rフレーズ | 22 | | WGK Germany | 3 | | HSコード | 2924296000 |
| | エトバベート Usage And Synthesis |
| 外観 | 白色〜わずかにうすい赤色, 結晶性粉末〜粉末 | | 溶解性 | メタノールに溶ける。 | | 用途 | 動物用医薬品定量用の標準品。ニワトリ、ブロイラーに用いる飼料添加物。 | | 用途 | 飼料添加用抗菌剤。 | | 効能 | 抗コクシジウム薬 | | 説明 | Ethopabate is a veterinary drug belonging to the class of antibiotics which contains an arylamide with a phenyl ring, a monocyclic aromatic hydrocarbon, and is a very safe drug used for the prophylaxis and treatment of coccidiosis in chickens. It has anticoccidial activity, especially against the intestinal form, and lacks activity against E. tenella of the cecum worm. The drug is a competitor of PABA, which is absorbed by the parasite and interferes with folate synthesis. It has good activity against E. acervulina and some strains of E. maxima and E. brunette. It is used only in combination with amprolium, first at a concentration of 4 ppm and later at a concentration of 40 ppm.This drug reaches peak activity on day 4 of the cycle. | | 化学的特性 | White to Off-White Solid | | 使用 | A supplementary drug that improves the coccidiostatic effect of nicarbazin and amprolium in order to cure coccidiosis in chickens. | | 使用 | antidepressant | | 定義 | ChEBI: Ethopabate is an amidobenzoic acid. | | 臨床応用 | Ethopabate is only a narrow anticoccidial spectrum drug against Eimeria acervulina. It has no or only slight activity against E. maxima, E. necatrix, E. tenella or E. brunetti. Today, ethopabate is applied only in combination with amprolium and sulfonamide. | | Molecular Interactions | Ethopabate is a 2-substituted PABA derivative (=4-acetamido-2-ethoxybenzoic acid methylester) and functions as a prodrug. Its activity becomes potentiated by pyrimethamine and antagonised by the simultaneous administration of PABA. Thus, the mode of action of ethopabate is similar to that of sulfonamides or sulfones. |
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