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| 化学名: | ジクラズリル | | 英語化学名: | Diclazuril | | 别名: | 2,6-Dichloro-a-(4-chlorophenyl)-4-[4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl]benzeneacetonitrile;Nuoqiu;Vecoxan;2-[3,5-Dichloro-4-(α-cyano-4-chlorobenzyl)phenyl]-1,2,4-triazine-3,5(2H,4H)-dione;2-[4-(4-Chloro-α-cyanobenzyl)-3,5-dichlorophenyl]-1,2,4-triazine-3,5(2H,4H)-dione;CLINACOX;DICLAZURIL;DICLAZUTIL | | CAS番号: | 101831-37-2 | | 分子式: | C17H9Cl3N4O2 | | 分子量: | 407.64 | | EINECS: | 1806241-263-5 | | カテゴリ情報: | Pharmaceuticals;Aromatics;Bases & Related Reagents;Heterocycles;Intermediates & Fine Chemicals;Nucleotides;Veterinaries;101831-37-2 | | Mol File: | 101831-37-2.mol |  |
| 融点 | 290.5° | | 比重(密度) | 1.56±0.1 g/cm3(Predicted) | | 貯蔵温度 | Inert atmosphere,Room Temperature | | 溶解性 | DMF: 5mg/mL; DMSO: 5mg/mL; DMSO:PBS (pH 7.2) (1:5): 0.16mg/mL | | 酸解離定数(Pka) | 5.89±0.20(Predicted) | | 色 | White to Light yellow to Light orange | | Merck | 14,3080 | | InChI | InChI=1S/C17H9Cl3N4O2/c18-10-3-1-9(2-4-10)12(7-21)16-13(19)5-11(6-14(16)20)24-17(26)23-15(25)8-22-24/h1-6,8,12H,(H,23,25,26) | | InChIKey | ZSZFUDFOPOMEET-UHFFFAOYSA-N | | SMILES | C1(C=C(C(C(C#N)C2=CC=C(Cl)C=C2)=C(Cl)C=1)Cl)N1N=CC(=O)NC1=O | | LogP | 2.439 (est) | | CAS データベース | 101831-37-2(CAS DataBase Reference) |
| Sフレーズ | 24/25 | | WGK Germany | 2 | | RTECS 番号 | CY1697600 | | HSコード | 29336990 |
| | ジクラズリル Usage And Synthesis |
| 外観 | 白色〜わずかにうすい黄色, 結晶性粉末〜粉末 | | 溶解性 | N,N-ジメチルホルムアミドに溶ける。 | | 用途 | HPLC用標準品 | | 効能 | 抗コクシジウム薬 (家禽用) | | 化学的特性 | Light yellow or off-white powder, almost insoluble in water, slightly soluble in ethanol, ether, soluble in N,N-2 methylformamide (DMF), dimethylsulfone (DMSO), tetrahydrofuran (THF). | | 使用 | Diclazuril is a triazinone antiprotozoal that Nucleotide analog with broad-spectrum anticoccidial activity. It has a control effect on a variety of coccidiosis, and is used to prevent coccidiosis in chickens, ducks, quails, turkeys, geese and rabbits. | | 定義 | ChEBI: 2-(4-chlorophenyl)-2-[2,6-dichloro-4-(3,5-dioxo-1,2,4-triazin-2-yl)phenyl]acetonitrile is a nitrile. | | 主な応用 | Diclazuril is a less toxic, orally administered triazine antiprotozoal. It is widely used in veterinary medicine as a feed additive and veterinary drug. It is registered for oral use in broilers and lambs. Its use in cats (one dose of 25 mg/kg BW) is off-label only. It may be used clinically for the treatment of bovine protozoa. It is also used for the treatment of equine protozoan spinal cord encephalitis (EPM) caused by neuronal sarcocysts. | | Veterinary Drugs and Treatments | Diclazuril is a coccidiostat. It is indicated for the treatment of equine protozoal myeloencephalitis (EPM) caused by Sarcocystis neurona and as a coccidiostat in broiler chickens. Diclazuril could potentially be useful in treating coccidiosis, Neospora caninum and Toxoplasma infections in dogs or cats. |
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