| Company Name: |
Shanghai Macklin Biochemical Co.,Ltd.
|
| Tel: |
15221275939 15221275939 |
| Email: |
shenlinxing@macklin.cn |
| Products Intro: |
Product Name:Compound 48/80 hydrochloride
CAS:848035-21-2
Purity:98% Package:10mg
|
| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
|
| Tel: |
400-9205774 |
| Email: |
sales@glpbio.cn |
| Products Intro: |
Product Name:Compound 48/80 (hydrochloride)
CAS:848035-21-2
Purity:>98% Package:1mg;10mg;50mg;100mg;
|
| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:Compound 48/80 trihydrochloride
CAS:848035-21-2
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
|
| | Compound 48/80 (hydrochloride) Basic information |
| | Compound 48/80 (hydrochloride) Chemical Properties |
| storage temp. | Store at -20°C, sealed storage, away from moisture ,protect from light | | solubility | Water: 100 mM | | form | A solid |
| | Compound 48/80 (hydrochloride) Usage And Synthesis |
| Biological Activity | Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of N-methyl-p-methoxyphenethylamine and formaldehyde condensation products. It is also a histamine releaser and mast cell degranulator. It inhibits the activity of phosphatidylinositol-specific phospholipase C in human platelets. | | in vitro | Compound 48/80 trihydrochloride (C48/80 trihydrochloride) inhibits both cytosolic and particulate phosphatidylinositol-specific phospholipase C activities with a similar efficiency; IC 50 values are 2.1 μg/ml (supernatant ) and 5.0 μg /ml (particulate fraction). The aggregation of human platelets induced by ADP and PAF-acether is inhibited by Compound 48/80. < /div> | | in vivo | Compound 48/80 trihydrochloride (0.75 mg/kg; ip; Killed after 0.5, 3 or 6 h) increases serum serotonin, histamine and corticosterone levels at 0.5 h, but their increases were reduced thereafter.
Compound 48/80 trihydrochloride causes oxidative stress in rat adrenal gland through mast cell degranulation. | Animal Model: | 7-week-old Wistar male rats (fasted for 24 hours) | | Dosage: | 0.75 mg/kg | | Administration: | Intraperitoneal injection; Killed after 0.5, 3 or 6 h | | Result: | Serum histamine and serotonin concentrations significantly higher than those in untreated control rats at 0.5 h after treatment. The increased serum histamine and serotonin conc entrations in rats decreased time-dependently thereafter. | |
| | Compound 48/80 (hydrochloride) Preparation Products And Raw materials |
|