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| | PF-6274484 Basic information |
| Product Name: | PF-6274484 | | Synonyms: | PF-6274484;N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-2-propenamide;2-Propenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-;PF-6274484 >=98% (HPLC);oxidation,autophosphorylation,PF6274484,PF-6274484,EGFR,signaling,Epidermal growth factor receptor,HER1,protein,ErbB-1,inhibit,kinase,cysteine,Inhibitor;N-(4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)acrylamide | | CAS: | 1035638-91-5 | | MF: | C18H14ClFN4O2 | | MW: | 372.78 | | EINECS: | | | Product Categories: | | | Mol File: | 1035638-91-5.mol |  |
| | PF-6274484 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 33 mg/ml; DMSO: 25 mg/ml | | form | A crystalline solid |
| | PF-6274484 Usage And Synthesis |
| Description | PF-6274484 is an irreversible EGFR kinase inhibitor that covalently reacts with active-site cysteine residues in the ATP binding pocket. PF-6274484 inhibits autophosphorylation of both wild type and mutant EGFR in tumor cells with IC50 values of 5.8 nM and 6.6 nM, respectively. |
| | PF-6274484 Preparation Products And Raw materials |
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