Company Name: |
ShangHai KenEn Chemical Technology Co., Ltd.
|
Tel: |
13120367189 |
Email: |
mychess007@163.com |
Products Intro: |
Product Name:7-(3-(pyrrolidin-1-yl)propoxy)-6-methoxy-2-(5-methylfuran-2-yl)-N-((1-methylpiperidin-4-yl)methyl)quinolin-4-amine CAS:1846570-40-8 Purity:98% Package:10MG/
|
|
| 7-(3-(pyrrolidin-1-yl)propoxy)-6-methoxy-2-(5-methylfuran-2-yl)-N-((1-methylpiperidin-4-yl)methyl)quinolin-4-amine Basic information |
| 7-(3-(pyrrolidin-1-yl)propoxy)-6-methoxy-2-(5-methylfuran-2-yl)-N-((1-methylpiperidin-4-yl)methyl)quinolin-4-amine Chemical Properties |
Boiling point | 641.8±55.0 °C(Predicted) | density | 1.143±0.06 g/cm3(Predicted) | storage temp. | Store at -20°C | solubility | Soluble in DMSO | pka | 10.09±0.20(Predicted) |
| 7-(3-(pyrrolidin-1-yl)propoxy)-6-methoxy-2-(5-methylfuran-2-yl)-N-((1-methylpiperidin-4-yl)methyl)quinolin-4-amine Usage And Synthesis |
Description | CM-579 is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells[1]. The Kd of CM-579 for DNMT1 is 1.5 nM, CM-579 also inhibits DNMT3A and DNMT3B, with IC50s of 92 nM and 1000 nM, respectively[1]. | References | [1]. San José-Enériz E, et al. Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies. Nat Commun. 2017 May 26;8:15424. |
| 7-(3-(pyrrolidin-1-yl)propoxy)-6-methoxy-2-(5-methylfuran-2-yl)-N-((1-methylpiperidin-4-yl)methyl)quinolin-4-amine Preparation Products And Raw materials |
|