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| | 1,2-ベンゾイソチアゾール-3(2H)-オン 製品概要 |
| | 1,2-ベンゾイソチアゾール-3(2H)-オン 物理性質 |
| 融点 | 154-158 °C(lit.) | | 沸点 | 360°C (rough estimate) | | 比重(密度) | 1.2170 (rough estimate) | | 蒸気圧 | 0Pa at 25℃ | | 屈折率 | 1.5500 (estimate) | | 貯蔵温度 | Keep in dark place,Sealed in dry,Room Temperature | | 溶解性 | Soluble in dichloromethane, dimethyl sulfoxide, methanol. | | 酸解離定数(Pka) | 10.19±0.20(Predicted) | | 色 | White to Light yellow to Light orange | | 水溶解度 | 1.288g/L at 20℃ | | InChIKey | DMSMPAJRVJJAGA-UHFFFAOYSA-N | | LogP | 0.7 at 20℃ | | CAS データベース | 2634-33-5 | | EPAの化学物質情報 | 1,2-Benzisothiazolin-3-one (2634-33-5) |
| | 1,2-ベンゾイソチアゾール-3(2H)-オン Usage And Synthesis |
| 外観 | 白色～うすい黄褐色、結晶～結晶性粉末 | | 用途 | 工業用防腐?防カビ剤 | | 説明 | BIT (1,2-Benzisothiazol-3(2H)-one) is an irritant and also
a skin sensitizer. Occupational allergie contact dermatitis
has been reported mainly related to the use of
cutting oils and greases in paint manufacturers,
pottery mouldmakers, acrylic emulsion manufacturers,
plumbers, printers and lithoprinters, paper makers, an
analyticallaboratory, a rubber factory, and in employees
manufacturing air fresheners. | | 化学的特性 | Yellow Powder | | 使用 | Isothiazolinone BIT is widely used in industry as a
preservative in water-based solutions, such as pastes,
paints and cutting oils. It exists at different concentrations
in the different Proxel AB, GXL, CRL, XL2, XL,
HL, TN, and in Mergal K-10. | | 使用 | Antimicrobial agent. | | 定義 | ChEBI: Benzo[d]isothiazol-3-one is an organic heterobicyclic compound based on a fused 1,2-thiazole and benzene bicyclic ring skeleton, with the S atom positioned adjacent to one of the positions of ring fusion. It has a role as a disinfectant, a platelet aggregation inhibitor, an environmental contaminant, a xenobiotic, a drug allergen and a sensitiser. It is an organonitrogen heterocyclic compound and an organic heterobicyclic compound. | | 主な応用 | 1,2-benzisothiazol-3(2H)-one (BIT) has been widely used in high concentrations for microbial growth control in many domestic and industrial processes, its potential eco-risk should be assessed. | | 一般的な説明 | 1,2-Benzisothiazol-3(2H)-one is a commonly used biocide in industrial and consumer products, which possesses antimicrobial activity against gram positive and gram negative bacteria. It is mainly used in packaging, adhesives, detergents, disinfectants, sunscreen lotions, paints and lubricants. | | 燃焼性と爆発性 | Not classified | | 接触アレルゲン | 1,2-Benzisothiazol-3(2H)-one, both an irritant and a skin sensitizer, is widely used
in industry as a preservative in water-based solutions
such as pastes, paints, and cutting oils. Occupational
dermatitis has been reported mainly due to cutting fluids
and greases, in paint manufacturers, pottery moldmakers,
acrylic emulsions manufacturers, plumber,printers and lithoprinters, paper makers, analytical laboratory,
rubber factory, and employees manufacturing air
fresheners. It is also a preservative in vinyl gloves. | | 安全性プロファイル | Moderately toxic by ingestion.When heated to decomposition it emits toxic vapors ofNOx and SOx. | | Toxicity evaluation | Isothiazolinones, such as 1,2-benzisothiazol-3(2H)-one (BIT), are widely used as biocides for bacterial growth control in many domestic and industrial processes. Despite their advantages as biocides, they are highly toxic and pose a potential risk to the environment. BIT could seriously inhibit the growth of Scenedesmus sp. LX1, Chlorella sp. HQ, and Chlamydomonas reinhardtii with half maximal effective concentrations at 72 h (72h-EC50) of 1.70, 0.41, and 1.16 mg/L, respectively. The primary inhibition mechanism was the BIT-induced damage to microalgal photosynthetic systems. |
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