L-抗坏血酸-2-单磷酸酯三环己铵盐
| 中文名称 | L-抗坏血酸-2-单磷酸酯三环己铵盐 |
|---|---|
| 中文同义词 | L-抗坏血酸-2-单磷酸酯三环己铵盐;维生素C磷酸酯(L-抗坏血酸-2-磷酸酯);化合物 T19390;2-磷酸抗坏血酸 |
| 英文名称 | L-ASCORBIC ACID 2-MONOPHOSPHATE TRI-CYCLOHEXYLAMMONIUM SALT |
| 英文同义词 | Vitamin C phosphate;l-ascorbic acid 2-monophosphate tris-cyclohexylammonium salt;ascorbate-2-phosphate;Ascorbyl monophosphate;Ascorbyl-2-monophosphate;Ascorbyl-2-phosphate;L-Ascorbic acid, 2-(dihydrogen phosphate);[2-(1,2-dihydroxyethyl)-3-hydroxy-5-oxo-2H-furan-4-yl] dihydrogen phosphate |
| CAS号 | 23313-12-4 |
| 分子式 | C6H9O9P |
| 分子量 | 256.1 |
| EINECS号 | 601-297-5 |
| 相关类别 | 中间体;有机化工原料;食品添加剂;维生素C 系列 |
| Mol文件 | 23313-12-4.mol |
| 结构式 |  |
L-抗坏血酸-2-单磷酸酯三环己铵盐 性质
| 沸点 | 682.7±65.0 °C(Predicted) |
|---|---|
| 密度 | 2.01±0.1 g/cm3(Predicted) |
| 酸度系数(pKa) | 1.38±0.10(Predicted) |
IC50: alkaline phosphatase (ALP); collagen formation; runx2A
L-Ascorbic acid 2-phosphate (0.1-1.5 mM; 2 to 3 weeks with medium exchange every 2 to 3 days) significantly stimulates cell growth, whereas addition of l-Ascorbic acid (Asc) achieves only weak growth stimulation. A combination of Asc-2P and bFGF significantly increases cell growth, but supplementation with EGF and/or insulin does not have any additional effect . L-Ascorbic acid 2-phosphate (50 µM-250 µM) is needed for the effective osteogenic differentiation of human adipose stem cells (hASCs), and higher concentrations of AsA2-P results in increased runx2 expression and ALP activity. The highest proliferation, ALP activity and runx2 expression is achieved with 150 µM AsA2-P and 10 nM dexamethasone (Dex), and 250 µM AsA2-P and 5 nM Dex.
Cell Proliferation Assay
| Cell Line: | Human corneal endothelial cells (HCECs) |
| Concentration: | 0.1 mM; 0.3 mM; 1.5 mM |
| Incubation Time: | 2 to 3 weeks with medium exchange every 2 to 3 days |
| Result: | Stimulated HCEC cells growth. |