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ChemicalBook Optimization Suppliers |
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| 主な危険性 | C | | Rフレーズ | 34-37 | | Sフレーズ | 26-36/37/39-45 | | RIDADR | UN 3265 8/PG 2 | | WGK Germany | 3 | | RTECS 番号 | TD4393000 | | F | 10 | | TSCA | Yes | | 国連危険物分類 | 8 | | 容器等級 | II | | HSコード | 29209085 |
| | ジクロロりん酸フェニル Usage And Synthesis |
| 外観 | 無色～うすい黄色、液体 | | 使用上の注意 | 窒素封入 | | 化学的特性 | clear colourless to very slightly brown liquid | | 使用 | Reagent for the preparation of phosphate diesters. | | 使用 | Reagent for preparation of phosphate diesters. Phenyl dichlorophosphate is used in the preparation of symmetrical phosphate diesters. It is used as a phosphorylating agent for alcohols and amines. It is also involved in the preparation of phenylphosphoro di-(1-imidazolidate) and 2-phenyl-bis-triazoloylphosphate, which is used in peptide synthesis. It plays a vital role in the Pfitzner-Moffatt oxidation which involves oxidation of alcohols to the corresponding aldehydes and ketones. Furthermore, it is utilized in Beckmann rearrangement for the preparation of N-phenylacetamide from acetophenone oxime. | | 使用 | In organic synthesis for preparation of lactams, phosphate diesters and for oxidation reactions. | | 製造方法 | The preparation of Phenyl dichlorophosphate is as follows:160 g (1 mol) of phosphorus oxychloride and 1 g of titanium tetrachloride were respectively added to a four-necked flask to carry out the reaction, and the temperature was raised to 70-80° C., and phenol (94 g, 1 mol) was slowly added dropwise. The phenol addition time was about 2- 3 hours,After completion of the dropwise addition, the reaction is maintained at 80-90° C. for 3-5 hours. After no hydrogen chloride is evolved, the reaction is completed. After the reaction, the phosphorus oxychloride is distilled under reduced pressure, the vacuum degree is 30-100 KPa, and the distillation temperature is 30-100° C. Distillation under reduced pressure to obtain the intermediate of the mixture, a mono-substituted and di-substituted mixture of phosphorus oxychloride, the ratio of the mixture is 5:5, gas phase analysis to obtain the intermediate of the mixture, the yield of the intermediate is 95%, phosphorus oxychloride The recovery rate is 95% (calculated as phosphorus oxychloride). 
| | 一般的な説明 | A liquid. May severely irritate skin, eyes and mucous membranes. | | 空気と水の反応 | About the same density as water and moderately soluble in water. | | 反応プロフィール | An hologenated organophosphate. Organophosphates are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides. | | 危険性 | May cause severe skin, eye, and mucous membrane irritation; Reacts violently with water; Causes burns; Inhalation may cause
corrosive injuries to upper respiratory tract and lungs; Toxic by
ingestion; Highly toxic by skin absorption; Dermal LD50 (guinea pig) =
14-400 mg/kg. | | 健康ハザード | TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. | | 火災危険 | Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. |
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