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| | (25R)-3β-ヒドロキシ-5α-スピロスタン 製品概要 |
| 化学名: | (25R)-3β-ヒドロキシ-5α-スピロスタン | | 英語化学名: | Tigogenin | | 别名: | TIGOGENIN;(25r)-5-alpha-spirostan-3-beta-o;25R,5ALPHA-SPIROSTAN-3BETA-OL;5-ALPHA, 20-ALPHA, 22-ALPHA, 25D-SPIROSTAN-3-BETA-OL;(25R)-5-Spirostan-3-ol;(3-beta,5-alpha,25r)-spirostan-3-o;5-alpha-spirostan-3-beta-ol;5alpha-Spirostan-3beta-ol, (25R)- | | CAS番号: | 77-60-1 | | 分子式: | C27H44O3 | | 分子量: | 416.64 | | EINECS: | 201-041-9 | | カテゴリ情報: | Miscellaneous Natural Products | | Mol File: | 77-60-1.mol |  |
| | (25R)-3β-ヒドロキシ-5α-スピロスタン 物理性質 |
| 融点 | 202-204°C | | 比旋光度 | -68 º (c=0.8g/100ml, CHCl3) | | 沸点 | 474.91°C (rough estimate) | | 比重(密度) | 1.0362 (rough estimate) | | 屈折率 | 1.4700 (estimate) | | 貯蔵温度 | -20°C Freezer, Under inert atmosphere | | 溶解性 | Chloroform (Slightly) | | 外見 | Solid | | 酸解離定数(Pka) | 15.14±0.70(Predicted) | | 色 | Off-White | | CAS データベース | 77-60-1(CAS DataBase Reference) | | NISTの化学物質情報 | Tigogenin(77-60-1) |
| | (25R)-3β-ヒドロキシ-5α-スピロスタン Usage And Synthesis |
| 説明 | Tigogenin is a steroidal sapogenin that has been found in A. sisalana and has diverse biological activities. It increases the proliferation rate of, as well as mRNA levels of genes encoding the osteoblastic differentiation markers Cbfa1, collagen type I, and osteocalcin in, mouse bone marrow stromal cells (BMSCs) in a concentration-dependent manner. It also increases matrix calcium deposition in BMSCs when used at concentrations of 30 and 90 μM. Tigogenin is active against the fungus A. fumigatus (MIC50 = 16 μg/ml). It inhibits carrageenan-induced paw edema in rats when administered at a dose of 4.2 μg/kg. | | 化学的特性 | mp 196-208C° LOD ≤0.5% | | 使用 | Tigogenin is a saponin structurally similar to Diosgenin (D484700) and acts as a natural plant steroid which induces apoptosis in rheumatoid arthritic fibroblast-like synoviocytes. | | 定義 | ChEBI: Tigogenin is a widely used steroidal sapogenin isolated from several plant species and used for synthesizing steroid drugs. It has a role as a gout suppressant and a plant metabolite. |
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