| 融点 | 80-83 °C(lit.) | | 沸点 | 242 °C(lit.) | | 比重(密度) | 1.298 g/mL at 25 °C(lit.) | | 蒸気密度 | 5.4 (vs air) | | 蒸気圧 | 0.09 mm Hg ( 25 °C) | | 屈折率 | 1.5376 (estimate) | | 闪点 | >230 °F | | 溶解性 | Soluble in acetone and alcohol (Weast, 1986) | | 外見 | Crystals or Flakes | | 色 | Yellow | | 水溶解度 | Insoluble | | Merck | 14,2151 | | BRN | 508691 | | Henry's Law Constant | 4.90 x 10-6 atm?m3/mol at 25 °C (thermodynamic method-GC/UV spectrophotometry, Altschuh et al., 1999) | | 暴露限界値 | Potential occupational carcinogen. NIOSH REL: IDLH 100; OSHA
PEL: TWA 1. | | 安定性： | Stable. Combustible. Incompatible with strong oxidizing agents, hydroxides. Reacts violently with sodium methoxide in methanol. | | InChIKey | CZGCEKJOLUNIFY-UHFFFAOYSA-N | | CAS データベース | 100-00-5(CAS DataBase Reference) | | IARC | 2B (Vol. 65, 123) 2020 | | NISTの化学物質情報 | Benzene, 1-chloro-4-nitro-(100-00-5) | | EPAの化学物質情報 | p-Chloronitrobenzene (100-00-5) |
| | 4-クロロニトロベンゼン Usage And Synthesis |
| 外観 | うすい黄色～黄色～緑色粉末～結晶 | | 用途 | 染料、農薬、酸化防止剤、オイル添加剤、抗マラリア薬およびゴム薬品。 | | 物理的性質 | p-Nitrochlorobenzene is a yellow crystalline solid with a sweet odor. | | 化学的特性 | 4-Chloronitrobenzene is a light yellow monoclinic prisms crystallizes, which are insoluble in water and very soluble in toluene, ether, acetone, or hot ethanol. It is incompatible with strong oxidizers and alkalis. It is extensively used in different industries as an intermediate in the manufacture of dyes, rubber, and agricultural chemicals. | | 使用 | 4-Nitrochlorobenzene is an important intermediate in the manufacture of azo dyes and sulfide dyes, the drugs finasteride and paracetamol, the pesticide herbicide, etc. It is also the raw material of rubber antioxidant 4010. | | 使用 | Manufacture of dyes, rubber, and agricultural
chemicals | | 使用 | p-Nitrochlorobenzene is largely used to produce p-nitrophenol with smaller production of p-nitroaniline. | | 調製方法 | p-Nitrochlorobenzene is made by the nitration of chlorobenzene. | | 定義 | ChEBI: 4-Chloronitrobenzene is a C-nitro compound. | | Synthesis Reference(s) | The Journal of Organic Chemistry, 52, p. 2407, 1987 DOI: 10.1021/jo00388a014
Tetrahedron Letters, 19, p. 4519, 1978 | | 一般的な説明 | Light yellow crystalline solid. Density 1.520 g / cm3. Melting point 83°C. Sweet odor. Very toxic by inhalation, ingestion, and skin absorption. p-Chloronitrobenzene is extensively used in different industries as an intermediate in the manufacture of dyes, rubber, and agricultural chemicals. It is incompatible with strong oxidisers and alkalis. | | 空気と水の反応 | Insoluble in water. | | 反応プロフィール | 4-Chloronitrobenzene reacts with oxidizing agents. Reacts violently and finally explosively when added to a solution of sodium methoxide in methanol. . Unstable when heated. | | 危険性 | A questionable carcinogen. Very toxic by
inhalation and ingestion. Absorbed via skin. Combustible. Methemoglobinemia. | | 健康ハザード | Repeated exposure to high levels of p-chloronitrobenzene causes adverse health effects.
The symptoms of toxicity include, but are not limited to, anoxia, unpleasant taste, anemia, methemoglobinemia, hematuria (blood in the urine), spleen, kidney, bone marrow
changes, and reproductive effects. The target organs of p-chloronitrobenzene poisoning
have been identifi ed as the blood, liver, kidneys, cardiovascular system, spleen, bone
marrow, and reproductive system. | | 火災危険 | 4-Chloronitrobenzene is combustible. | | 安全性プロファイル | Confirmed carcinogen
with experimental carcinogenic data. A
poison by ingestion. Experimental
reproductive effects. Mutation data
reported. Flammable liquid when exposed to
heat, sparks, or flame. May explode on
heating. Potentially violent reaction with
sodium methoxide. When heated to
decomDosition it emits very toxic fumes of NOx and Cl-. See also other
chloronitrobenzene entries and NITRO
COMPOUNDS OF AROMATIC
HYDROCARBONS. | | 職業ばく露 | p-Nitrochlorobenzene (PNCB) is used
as an intermediate in pesticide (parathion) manufacture,
drug (phenacetin and acetaminophen) manufacture; and in
dye making; rubber and antioxidant manufacture. | | 発がん性 | No increase in tumor incidence was seen
in rats fed up to 1000 ppm in the diet for 2
years; in mice, results were equivocal, with
high-dose animals showing an increase in vascular
tumors and low-dose males showing an
increase in liver tumors.6 The IARC has determined
that there is inadequate evidence in
experimental animals and humans for the carcinogenicity
of chlorobenzenes.7 | | 環境運命予測 | Biological. Under aerobic conditions, the yeast Rhodosporidium sp. metabolized pchloronitrobenzene
to 4-chloroacetanilide and 4-chloro-2-hydroxyacetanilide as final major
metabolites. Intermediate compounds identified include 4-chloronitrosobenzene, 4-chlorophenylhydroxylamine,
and 4-chloroaniline (Corbett and Corbett, 1981).
Under continuous flow conditions involving feeding, aeration, settling, and reflux, a mixture of
p-chloronitrobenzene and 2,4-dinitrochlorobenzene was reduced 61–70% after 8–13 d by
Arthrobacter simplex, a microorganism isolated from industrial waste. A similar experiment was
conducted using two aeration columns. One column contained A. simplex, the other a mixture of
A. simplex and microorganisms isolated from soil (Streptomyces coelicolor, Fusarium sp.,
probably aquaeductum and Trichoderma viride). After 10 d, 89.5–91% of the nitro compounds
was reduced. p-Chloronitrobenzene was reduced to 4-chloroaniline and six unidentified
compounds (Bielaszczyk et al., 1967).
Photolytic. An aqueous solution containing p-chloronitrobenzene and a titanium dioxide
(catalyst) suspension was irradiated with UV light (λ >290 nm). 2-Chloro-5-nitrophenol was the
only compound identified as a minor degradation product. Continued irradiation caused additional
degradation yielding carbon dioxide, water, hydrochloric and nitric acids (Hustert et al., 1987).
Irradiation of p-chloronitrobenzene in air and nitrogen produced 4-chloro-2-nitrophenol and 4-
chlorophenol, respectively (Kanno and Nojima, 1979).
Chemical. Although no products were identified, p-chloronitrobenzene (1.5 x 10-5 M) was
reduced by iron metal (33.3 g/L acid washed 18–20 mesh) in a carbonate buffer (1.5 x 10-2 M) at
pH 5.9 and 15 °C. Based on the pseudo-first-order disappearance rate of 0.0336/min, the half-life
was 20.6 min (Agrawal and Tratnyek, 1996). | | 輸送方法 | UN1578 Chloronitrobenzenes, solid or liquid,
Hazard Class: 6.1; Labels: 6.1-Poisonous materials. | | 純化方法 | Crystallise the nitrobenzene from 95% EtOH (charcoal) and sublime it in vacuo. [Emmons JAm Chem Soc 76 3470 1954, Newman & Forrest J Am Chem Soc 69 1221 1947, Beilstein 5 IV 723.] | | 不和合性 | A strong oxidizer. Reacts violently with
oxidizers, combustibles, alkalis, sodium methoxide; and
reducing materials. | | 廃棄物の処理 | Incineration (816℃, 0.5 second
for primary combustion; 1204℃, 1.0 second for secondary
combustion). The formation of elemental chlorine
can be prevented through injection of steam or methane
into the combustion process. nitrogen oxides may be abated
through the use of thermal or catalytic devices. |
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