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1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE(79183-19-0)

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1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE 製品概要
化学名:
英語化学名:1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE
别名:APOPTOSIS ACTIVATOR 2;APOPTOSIS ACTIVATOR II;1-[(3,4-DICHLOROPHENYL)METHYL]-1H-INDOLE-2,3-DIONE;1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE;1H-Indole-2,3-dione, 1-[(3,4-dichlorophenyl)methyl]-;Apoptosis Activator 2, >=98%;Apoptosis Activator 2, 97%, a cytochrome c caspase activator and apoptosis inducer;CS-572
CAS番号:79183-19-0
分子式:C15H9Cl2NO2
分子量:306.14
EINECS:200-256-5
カテゴリ情報:Inhibitors;Caspases/Apoptosis
Mol File:79183-19-0.mol
1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE
1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE 物理性質
沸点 470.6±55.0 °C(Predicted)
比重(密度) 1.494
闪点 238.4℃
貯蔵温度 Keep in dark place,Sealed in dry,2-8°C
溶解性Soluble in DMSO
外見 Orange to red solid.
酸解離定数(Pka)-2.69±0.20(Predicted)
Sensitive Light Sensitive
安全性情報
Sフレーズ 24/25
RIDADR 3077
HSコード 29145090
MSDS Information
1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE Usage And Synthesis
使用Activates apoptosis in cells; shows selectivity for cancer cells against normal cell lines
使用Apoptosis Activator 2 activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells.
定義ChEBI: 1-[(3,4-dichlorophenyl)methyl]indole-2,3-dione is a member of indoles.
生物活性Apoptosis activator; promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC 50 = 4-9 μ M for leukaemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC 50 > 40 μ M).
貯蔵Room temperature
参考文献[1] nguyen jt, wells ja. direct activation of the apoptosis machinery as a mechanism to target cancer cells. proc natl acad sci u s a. 2003 jun 24;100(13):7533-8.
[2] nguyen tv, jayaraman a, quaglino a, pike cj. androgens selectively protect against apoptosis in hippocampal neurones. j neuroendocrinol. 2010 sep;22(9):1013-22.
Tags:79183-19-0