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| | 4-(2-アミノエチル)ベンゼンスルホニルフルオライド塩酸塩 製品概要 |
| 化学名: | 4-(2-アミノエチル)ベンゼンスルホニルフルオライド塩酸塩 | | 英語化学名: | 4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride | | 别名: | 4-(Fluorosulphonyl)phenethylamine hydrochloride, 2-[4-(Fluorosulphonyl)phenyl]ethylamine hydrochloride, AEBSF;Benzenesulfonyl fluoride, 4-(2-aMinoethyl)-, hydrochloride (1:1);4-(2-AMinoethyl)benzenesulfonyl fluoride hydrochlorid;4-(2-Aminoethyl)-benzenesulfonyl fluoride hydrochloride (1:1);BROMOPHENOL BLUE NA SALT PROTEOMICS GR;AEBSF HCI;4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE HYDROCHLORIDE;4-(2-AMINOETHYL)BENZENESULPHONYL FLUORIDE HYDROCHLORIDE | | CAS番号: | 30827-99-7 | | 分子式: | C8H11ClFNO2S | | 分子量: | 239.69 | | EINECS: | 608-547-2 | | カテゴリ情報: | ProteaseInhibitors;inhibitor;Inhibitors | | Mol File: | 30827-99-7.mol |  |
| | 4-(2-アミノエチル)ベンゼンスルホニルフルオライド塩酸塩 物理性質 |
| 融点 | 175-177 °C | | 貯蔵温度 | 2-8°C | | 溶解性 | H2O: soluble50mg/mL (stable for up to six months if stored refrigerated at a pH of less than 7. If a pH of greater than 7 is required, pH adjustment should be made just prior to use.) | | 外見 | Powder | | 色 | White | | PH | pH3.0～5.0 (10g/L, 25℃) | | 水溶解度 | 10 g/L (20 ºC) | | Sensitive | Moisture Sensitive | | BRN | 7604627 | | 安定性： | Stable for 1 year from date of purchase as supplied. Solutions at pH <7 are stable for up to 6 months if stored in the refrigerator | | InChIKey | WRDABNWSWOHGMS-UHFFFAOYSA-N | | CAS データベース | 30827-99-7(CAS DataBase Reference) |
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ACROS
| English |
| | 4-(2-アミノエチル)ベンゼンスルホニルフルオライド塩酸塩 Usage And Synthesis |
| 外観 | 白色～ほとんど白色, 結晶性粉末～粉末 | | 溶解性 | 水に可溶。 | | 用途 | 酵素の精製、組織培養。 | | 使用上の注意 | 安定性室温3ヶ月, 冷蔵6ヶ月(溶解後) | | 説明 | AEBSF is a water soluble, irreversible, broad spectrum inhibitor of serine proteases, including trypsin, chymotrypsin, plasmin, thrombin, and kallikreins. AEBSF can also prevent the activation of the ROS generator, NADPH oxidase. At 10-50 μg, AEBSF can attenuate airway inflammation in a mouse model of airway allergy. AEBSF maintains stability in slightly acidic aqueous solutions and serves as a nontoxic alternative to the organophosphate inhibitors, PMSF and DFP. | | 化学的特性 | white powder | | 使用 | Recommended concentrations for use are 0.1-1 mM. | | 使用 | AEBSF is extensively used in studies aiming to describe cholesterol regulatory genes due to its potent ability to inhibit Site-1-protease (S1P). This serine protease, located in the Golgi apparatus, is responsible for activating the sterol regulatory element-binding proteins. By selectively inhibiting S1P, AEBSF can be used to characterize the downstream result of SREBP inhibition and its influence on cholesterol regulation. | | 一般的な説明 | Pefabloc? SC is a trypsin inhibitor, which can be used in the synthesis of its arginine-like analogue, 4-(2-guanidinoethyl)benzenesulfonyl fluoride. | | Biochem/physiol Actions | Irreversible serine protease inhibitor. Inhibition constants are similar to those of PMSF and DFP. AEBSF has been shown to inhibit trypsin, chymotrypsin, plasmin kallikrein and thrombin. As an alternative to PMSF and DFP, AEBSF offers lower toxicity, improved solubility in water and improved stability in aqueous solutions. AEBSF has been used in cell culture in concentrations of up to 0.25?mM. | | 貯蔵 | Store at -20°C | | 参考文献 | 1) Powers?et al. (2002),?Irreversible inhibitors of serine, cysteine and threonine proteases; Chem. Rev.,?102?4639
2) Diatchuk?et al.?(1997),?Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds; J. Biol. Chem.,?272?13292 |
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