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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767 |
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Product Name:YW3-56 hydrochloride CAS:2309756-20-3 Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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TargetMol Chemicals Inc.
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4008200310 |
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marketing@tsbiochem.com |
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Product Name:YW3-56 (hydrochloride) (technical grade);YW3 56 (hydrochloride) (technical grade),YW356 (hydrochloride) (technical grade),YW-3-56 (hydrochloride) (technical grade) CAS:2309756-20-3 Purity:98% Package:5 mg
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Company Name: |
A2B Chem LLC
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010 |
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sales@a2bchem.com |
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Product Name:N-[(1S)-4-[(2-chloro-1-iminoethyl)amino]-1-[[(phenylmethyl)amino]carbonyl]butyl]-6-(dimethylamino)-2-naphthalenecarboxamide,monohydrochloride CAS:2309756-20-3
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Company Name: |
1Pluschem LLC
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(858)215-1656 |
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sales@1pchem.com |
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CAS:2309756-20-3
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| N-[(1S)-4-[(2-chloro-1-iminoethyl)amino]-1-[[(phenylmethyl)amino]carbonyl]butyl]-6-(dimethylamino)-2-naphthalenecarboxamide,monohydrochloride Basic information |
| N-[(1S)-4-[(2-chloro-1-iminoethyl)amino]-1-[[(phenylmethyl)amino]carbonyl]butyl]-6-(dimethylamino)-2-naphthalenecarboxamide,monohydrochloride Chemical Properties |
storage temp. | Store at -20°C | solubility | Methanol: 10 mg/ml |
| N-[(1S)-4-[(2-chloro-1-iminoethyl)amino]-1-[[(phenylmethyl)amino]carbonyl]butyl]-6-(dimethylamino)-2-naphthalenecarboxamide,monohydrochloride Usage And Synthesis |
Biological Activity | YW3-56 is an inhibitor of protein arginine deiminase 2 (PAD2) and PAD4 (IC50s = 0.5-1 and 1-5 μM, respectively).1 It inhibits the growth of U2OS osteosarcoma cells (IC50 = ~2.5 μM) in a p53-dependent manner via induction of SESN2 and subsequent inhibition of mTORC1. YW3-56 (10 mg/kg) reduces tumor growth in an S-180 murine sarcoma tumor model. It also inhibits tumor growth in the 1883 MDA-MB-231 breast cancer bone metastasis mouse xenograft model.2 | References | 1.Wang, Y., Li, P., Wang, S., et al.Anticancer peptidylarginine deiminase (PAD) inhibitors regulate the autophagy flux and the mammalian target of rapamycin complex 1 activityThe Journal of Biological Chemisty287(31)25941-25952(2012)
2.Wang, S., Chen, X.A., Hu, J., et al.ATF4 gene network mediates cellular response to the anticancer PAD inhibitor YW3-56 in triple-negative breast cancer cellsMol. Cancer Ther.14(4)877-888(2015) |
| N-[(1S)-4-[(2-chloro-1-iminoethyl)amino]-1-[[(phenylmethyl)amino]carbonyl]butyl]-6-(dimethylamino)-2-naphthalenecarboxamide,monohydrochloride Preparation Products And Raw materials |
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