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| | 3,3,3-Trifluoro-2,2-dimethylpropionic acid Basic information |
| Product Name: | 3,3,3-Trifluoro-2,2-dimethylpropionic acid | | Synonyms: | 3,3,3-TRIFLUORO-2,2-DIMETHYLPROPIONIC A&;Propanoic acid, 3,3,3-trifluoro-2,2-diMethyl-;3,3,3-TRIFLUORO-2,2-DIMETHYLPROPIONIC;3,3-Trifluoro-2,2-diMethylpropionic acid;3,3,3-Trifluoro-2,2-dimethylpropionic acid 97%;2-(trifluoromethyl)-2-methylpropanoic acid;3,3,3-TRIFLUORO-2,2-DIMETHYLPROPIONIC A&;3,3,3-Trifluoro-2,2-dimethylpropionic acid | | CAS: | 889940-13-0 | | MF: | C5H7F3O2 | | MW: | 156.1 | | EINECS: | | | Product Categories: | C1 to C5;Carbonyl Compounds;Carboxylic Acids | | Mol File: | 889940-13-0.mol |  |
| | 3,3,3-Trifluoro-2,2-dimethylpropionic acid Chemical Properties |
| Melting point | 66-71 °C | | Boiling point | 76-77°C/14mm | | density | 1.278±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Chloroform (Slightly), Methanol (Slightly) | | pka | 3.10±0.10(Predicted) | | form | Solid | | color | White to Off-White | | InChI | InChI=1S/C5H7F3O2/c1-4(2,3(9)10)5(6,7)8/h1-2H3,(H,9,10) | | InChIKey | VMFSJVUPIXOCFO-UHFFFAOYSA-N | | SMILES | C(O)(=O)C(C)(C)C(F)(F)F | | CAS DataBase Reference | 889940-13-0 |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26 | | RIDADR | 3261 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HazardClass | 8 | | PackingGroup | III | | HS Code | 29159000 |
| | 3,3,3-Trifluoro-2,2-dimethylpropionic acid Usage And Synthesis |
| Uses | 3,3,3-Trifluoro-2,2-dimethylpropanoic Acid, is an organic buliding blocks, that can be used in the synthesis of variety of pharmaceutical compounds, such as inhibitors. | | Synthesis |
Prepare a dry, clean 1L four-necked flask. 18g of 3,3,3-trifluoro-2,2-dimethylpropanenitrile was added to it, and 500 ml of a 5 mol/L sodium hydroxide aqueous solution was placed in the flask; stir well; the mixture was heated to a temperature of 90-100 ° C and refluxed overnight. The reaction was terminated until 3,3,3-trifluoro-2,2-dimethylpropanenitrile was completely reacted. Concentrated hydrochloric acid was used to adjust the pH to 1. Continue stirring for 30 minutes, Extracted with 50*3ml of dichloromethane; the organic layers were combined and concentrated to give a white solid (3,3,3-Trifluoro-2,2-dimethylpropionic acid). The yield was 84.3% (GC 98%).
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| | 3,3,3-Trifluoro-2,2-dimethylpropionic acid Preparation Products And Raw materials |
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