AM555S,TAC-101 manufacturers
- Amsilarotene
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- $36.00
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2026-07-17
- CAS:125973-56-0
- Purity: 99.27%
- Supply Ability: 10g
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| | AM555S,TAC-101 Basic information |
| Product Name: | AM555S,TAC-101 | | Synonyms: | AM555S,TAC-101;AM 555S;AMsilarotene;AMsilarotene (TAC-101);4-[[3,5-Bis(trimethylsilyl)benzoyl]amino]benzoic acid;4-(3,5-bis(trimethylsilyl)benzamido)benzoic acid;CS-893;Benzoic acid,4-[[3,5-bis(trimethylsilyl)benzoyl]amino]- | | CAS: | 125973-56-0 | | MF: | C20H27NO3Si2 | | MW: | 385.6 | | EINECS: | | | Product Categories: | | | Mol File: | 125973-56-0.mol |  |
| | AM555S,TAC-101 Chemical Properties |
| Melting point | 280℃ (decomposition) | | Boiling point | 403.3±45.0 °C(Predicted) | | density | 1.10±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 100 mg/mL (259.34 mM; Need ultrasonic) | | form | Solid | | pka | 4.28±0.10(Predicted) | | color | White to off-white |
| | AM555S,TAC-101 Usage And Synthesis |
| Uses | Amsilarotene (TAC-101; Am 555S), an orally active synthetic retinoid, has selective affinity for retinoic acid receptor α (RAR-α) binding with Ki of 2.4, 400 nM for RAR-α and RAR-β. Amsilarotene induces the apoptotic of human gastric cancer, hepatocellular carcinoma and ovarian carcinoma cells. Amsilarotene can be used for the research of cancer[1][2][3]. | | in vivo | Amsilarotene (8 mg/kg/day orally for 30 days) inhibits the RMG-II tumor growth in nude mice[2]. | Animal Model: | 6-week-old female BALB/c nu/nu mice with subcutaneous RMG-II tumors[2] | | Dosage: | 8 mg/kg/day | | Administration: | Orally for 30 days | | Result: | The maximal tumor growth-inhibiting effect was seen on day 31 of administration, when there was a 45% reduction of relative tumor volume (RTV). |
| | References | [1] Sun SY, et al. Differential effects of synthetic nuclear retinoid receptor-selective retinoids on the growth of human non-small cell lung carcinoma cells. Cancer Res. 1997 Nov 1;57(21):4931-9. PMID:9354460
[2] Suzuki N, et al. A novel retinoid, 4-[3,5-bis (trimethylsilyl) benzamido] benzoic acid (TAC-101), induces apoptosis of human ovarian carcinoma cells and shows potential as a new antitumor agent for clear cell adenocarcinoma. Gynecol Oncol. 2004 Sep;94(3):643-9. DOI:10.1016/j.ygyno.2004.06.026
[3] Fujimoto K, et al. Induction of cell-cycle arrest and apoptosis by a novel retinobenzoic-acid derivative, TAC-101, in human pancreatic-cancer cells. Int J Cancer. 1999 May 17;81(4):637-44. DOI:10.1002/(sici)1097-0215(19990517)81:43.0.co;2-4 |
| | AM555S,TAC-101 Preparation Products And Raw materials |
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