|
ChemicalBook Optimization Suppliers |
|
| 化学名: | アンプロリウム塩酸塩 [生化学用] | | 英語化学名: | Amprolium Hydrochloride | | 别名: | amprol;amprol25;amprol25percent;mepyrium;pyridinium,1-((4-amino-2-propyl-5-pyrimidinyl)methyl)-2-methyl-,chloride,m;5-[(6-METHYLPYRIDIN-1-YL)METHYL]-2-PROPYL-PYRIMIDIN-4-AMINE CHLORIDE HYDROCHLORIDE;AMPROLIUM HYDROCHLORIDE;1-(4-amino-2-propylpyrimidin-5-ylmethyl)-2-methylpyridinium chloride hydrochloride | | CAS番号: | 137-88-2 | | 分子式: | C14H20Cl2N4 | | 分子量: | 315.24 | | EINECS: | 205-307-5 | | カテゴリ情報: | API;Antiparasitic | | Mol File: | 137-88-2.mol | ![アンプロリウム塩酸塩 [生化学用]](CAS/GIF/137-88-2.gif) |
| 融点 | 239.0 to 243.0 °C | | 貯蔵温度 | Inert atmosphere,Room Temperature | | 溶解性 | Methanol (Slightly), Water (Slightly) | | 外見 | Powder | | 色 | White to Off-white | | BRN | 4118699 | | InChI | InChI=1S/C14H19N4.2ClH/c1-3-6-13-16-9-12(14(15)17-13)10-18-8-5-4-7-11(18)2;;/h4-5,7-9H,3,6,10H2,1-2H3,(H2,15,16,17);2*1H/q+1;;/p-1 | | InChIKey | PJBQYZZKGNOKNJ-UHFFFAOYSA-M | | SMILES | C1(C=NC(CCC)=NC=1N)C[N+]1C=CC=CC=1C.Cl.[Cl-] | | CAS データベース | 137-88-2(CAS DataBase Reference) | | EPAの化学物質情報 | Amprolium hydrochloride (137-88-2) |
| | アンプロリウム塩酸塩 [生化学用] Usage And Synthesis |
| 外観 | 白色〜うすい黄色, 結晶性粉末〜粉末 | | 用途 | 高速液体クロマトグラフ法によるアンプロリウム定量用標準品。 | | 効能 | 抗原虫薬, 抗コクシジウム薬 (獣医薬) | | 説明 | Amprolium is a thiamine analog and antiprotozoal agent that interferes with thiamine metabolism and inhibits carbohydrate synthesis. It competitively inhibits thiamine uptake by E. tenella schizonts and by chick host intestinal cells (Kis = 7.6 and 326 μM, respectively). It also inhibits hexose formation and pentose utilization ex vivo in isolated lysed rat erythrocytes and in liver, kidney, heart, and intestinal tissue homogenates following dietary administration. Amprolium (1,000 ppm in feed) inhibits oocyst output and sporulation of Eimeria maxima, E. brunetti, and E. acervulina in infected chicks. It also decreases lesion and oocyst scores and mortality of E. tenella-infected chicks following dietary administration of a 125 ppm dose. Amprolium (100 μM) induces apoptosis in PC12 rat adrenal cells and increases the level of cleaved caspase-3. Formulations containing amprolium have been used as coccidiostats in poultry processing. | | 化学的特性 | Crystalline powder | | 使用 | 1-(4-Amino-2-n-propyl-5-pyrimidinylmethyl)-2-methylpyridinium Chloride is an antiparasytic drug used in the veterinary industry. In addition the compound shows anticoccidial activity. | | 使用 | Coccidiostatic;Thiamine transport inhibitor | | 使用 | Thiamine analog coccidiostat. | | 定義 | MeSH: Amprolium Hydrochloride is a veterinary coccidiostat that interferes with thiamine metabolism. | | 接触アレルゲン | Amprolium is an antiprotozoal agent used for the prevention
of coccidiosis in poultry. | | Veterinary Drugs and Treatments | Amprolium has good activity against Eimeria tenella and E. acervulina
in poultry and can be used as a therapeutic agent for these
organisms. It only has marginal activity or weak activity
against E. maxima, E. mivati, E. necatrix, or E. brunetti. It is often used in
combination with other agents (e.g., ethopabate) to improve control
against those organisms.
In cattle, amprolium has approval for the treatment and prevention
of E. bovis and E. zurnii in cattle and calves.
Amprolium has been used in dogs, swine, sheep, and goats for the
control of coccidiosis, although there are no approved products in
the USA for these species. |
|