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| | 1H-Indole-3-methanamine, N-decyl-1-[3-(dimethylamino)propyl]- 製品概要 |
| 化学名: | | | 英語化学名: | 1H-Indole-3-methanamine, N-decyl-1-[3-(dimethylamino)propyl]- | | 别名: | 1H-Indole-3-methanamine, N-decyl-1-[3-(dimethylamino)propyl]-;Dynole 2-24;Dynole 2-24, Dynamin I and II inhibitor | | CAS番号: | 1416313-72-8 | | 分子式: | C24H41N3 | | 分子量: | 371.6 | | EINECS: | | | カテゴリ情報: | | | Mol File: | 1416313-72-8.mol | ![1H-Indole-3-methanamine, N-decyl-1-[3-(dimethylamino)propyl]-](CAS/20210305/GIF/1416313-72-8.gif) |
| | 1H-Indole-3-methanamine, N-decyl-1-[3-(dimethylamino)propyl]- 物理性質 |
| 沸点 | 495.0±30.0 °C(Predicted) | | 比重(密度) | 0.96±0.1 g/cm3(Predicted) | | 貯蔵温度 | Store at -20°C | | 酸解離定数(Pka) | 10.27±0.19(Predicted) | | 外見 | Oil | | 色 | Colorless to light yellow |
| | 1H-Indole-3-methanamine, N-decyl-1-[3-(dimethylamino)propyl]- Usage And Synthesis |
| 説明 | Dynole 2-24 is an indole-based dynamin GTPase inhibitor (IC50=0.56 μM for dynamin I). Dynole 2-24 is nontoxic and shows increased potency against dynamin I and II in vitro and in cells (IC??(CME)=1.9 μM). Dynole 2-24 also shows 4.4-fold selectivity for dynamin I. Dynole 2-24 is active in-cell inhibitor of clathrin-mediated endocytosis[1]. CME: Clathrin mediated endocytosis | | 使用 | Dynole 2?24 is an indole-based dynamin GTPase inhibitor (IC50=0.56 μM for dynamin I). Dynole 2?24 is nontoxic and shows increased potency against dynamin I and II in vitro and in cells (IC??(CME)=1.9 μM). Dynole 2?24 also shows 4.4-fold selectivity for dynamin I. Dynole 2?24 is active in-cell inhibitor of clathrin-mediated endocytosis[1]. CME: Clathrin mediated endocytosis | | 参考文献 | [1] Gordon CP, Venn-Brown B, Robertson MJ, et al. Development of second-generation indole-based dynamin GTPase inhibitors. J Med Chem. 2013;56(1):46-59. DOI:10.1021/jm300844m |
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