左旋甲状腺素钠五水合物
中文名称 | 左旋甲状腺素钠五水合物 |
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中文同义词 | L-甲状腺素钠五水物;L-甲状腺素钠盐五水化合物;3-[4-(4-羟基-3,5-二碘苯氧基)-3,5-二碘苯基]-L-丙氨酸 钠盐;3',3,5',5-四碘甲腺原氨酸钠;O-(4-羟基-3,5-二碘苯基)-3,5-二碘-L-酪氨酸单钠盐五水合物;左旋甲状腺素钠五水合物;3',3,5',5-四碘甲腺原氨酸钠盐五水合物;L-腻,3',5'-四碘甲状腺氨酸钠/3',3,5',5-四碘甲腺原氨酸钠盐五水合物 |
英文名称 | Sodium levothyroxine pentahydrate |
英文同义词 | 3-[4-(4-HYDROXY-3,5-DIIODOPHENOXY)-3,5-DIIODOPHENYL]-L-ALANINE SODIUM SALT PENTAHYDRATE;3-[4-(4-HYDROXY-3,5-DIIODOPHENOXY)-3,5-DIIODOPHENYL]-L-ALANINE PENTAHYDRATE;3,3',5,5'-TETRAIODO-L-THYRONINE SODIUM SALT PENTAHYDRATE;(S)-2-AMINO-3-[4-(4-HYDROXY-3,5-DIIODOPHENOXY)-3,5-DIIODOPHENYL]PROPIONIC ACID SODIUM SALT PENTAHYDRATE;SODIUM (S)-2-AMINO-3-[4-(4-HYDROXY-3,5-DIIODOPHENOXY)-3,5-DIIODOPHENYL]PROPIONATE PENTAHYDRATE;SODIUM LEVOTHYROXINE PENTAHYDRATE;3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)-alaninmonosodiumsa;lt,pentahydrate, |
CAS号 | 6106-07-6 |
分子式 | C15H20I4NNaO9 |
分子量 | 888.93 |
EINECS号 | 682-494-3 |
相关类别 | 氨基酸;氨基酸类;生化试剂-氨基酸类;化学试剂;通用生化试剂-氨基酸;原料药;Hormones |
Mol文件 | 6106-07-6.mol |
结构式 |
左旋甲状腺素钠五水合物 性质
熔点 | 207-210 (dec.)(lit.) |
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比旋光度 | [α]D20 +15~+19° |
密度 | 2.381 |
储存条件 | 2-8°C |
溶解度 | 在细胞培养基的溶解度为0.1 mg/mL |
形态 | 粉末 |
颜色 | 白色到黄色到橙色 |
BRN | 5721845 |
CAS 数据库 | 6106-07-6(CAS DataBase Reference) |
Thyroid Hormone Receptor
Deiodinases (DIOs), which catalyse the conversion of thyroxine (pro-hormone) to the active thyroid hormone, are associated with thyroid stimulating hormone (TSH) levels. DIO1 and DIO2 catalyze activation of thyroid hormone secretion in contrast to DIO3 playing role inactivation of the secretion. Activities of DIO1 and DIO2 play pivotal role in the negative feedback regulation of pituitary TSH secretion. L-Thyroxine (T4) and Triiodothyronine (T3) hormones are known to modulate the expression of ionic channels, pumps and regulatory contractile proteins. Moreover, thyroid hormones have been shown to influence calcium homeostasis and flux responsible for excitation and contractility, with L-Thyroxine and Triiodothyronine modulating its pharmacological control and secretion. In rats fed 12 weeks with the iodine-free diet, a significant decrease in the levels of both Triiodothyronine and L-Thyroxine is observed when compared to the control group fed with standard diet (p<0.001). In the group treated with low doses of L-Thyroxine, an increase in L-Thyroxine levels is observed (p=0.02) while Triiodothyronine levels remain virtually similar to the control group (p=0.19). Rats treated with high doses of L-Thyroxine display a significant increase in both Triiodothyronine and L-Thyroxine circulating concentrations compared to the non-treated hypothyroid group (p<0.001 and p=0.004, respectively) and a significant increase in L-Thyroxine levels when compared to the control values (p=0.03).
安全信息
危险品标志 | Xn |
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危险类别码 | 40 |
安全说明 | 22-24/25-36 |
WGK Germany | 3 |
RTECS号 | YP2833760 |
F | 3-8-10 |
提供商 | 语言 |
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英文
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