| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:NBI 27914 hydrochloride;5-Chloro-N-(cyclopropylMethyl)-2-Methyl-N-propyl-N'-(2,4,6-trichlorophenyl)-4,6-pyriMidinediaMinehydrochloride
CAS:184241-44-9
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:NBI 27914
CAS:184241-44-9
Purity:>=98% (HPLC) Package:10mg, 50mg Remarks:N3911
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| Company Name: |
EMMX Biotechnology LLC
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| Tel: |
888-539-0666 |
| Email: |
info@emmx.com |
| Products Intro: |
Product Name:NBI 27914 hydrochloride
CAS:184241-44-9
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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| Company Name: |
Aikon International Limited
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| Tel: |
025-58851090 13611564524 |
| Email: |
lwan@aikonchem.com |
| Products Intro: |
CAS:184241-44-9
Purity:95% Package:5G;10G;100G
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| | 5-CHLORO-N-(CYCLOPROPYLMETHYL)-2-METHYL-N-PROPYL-N'-(2,4,6-TRICHLOROPHENYL)-4,6-PYRIMIDINEDIAMINE HYDROCHLORIDE Basic information |
| Product Name: | 5-CHLORO-N-(CYCLOPROPYLMETHYL)-2-METHYL-N-PROPYL-N'-(2,4,6-TRICHLOROPHENYL)-4,6-PYRIMIDINEDIAMINE HYDROCHLORIDE | | Synonyms: | 5-CHLORO-N-(CYCLOPROPYLMETHYL)-2-METHYL-N-PROPYL-N'-(2,4,6-TRICHLOROPHENYL)-4,6-PYRIMIDINEDIAMINE HYDROCHLORIDE;5-Chloro-N-(cyclopropylmethyl)-2-methyl-N-propyl-N'-(2,4,6-trichlorophenyl)-4,6-pyrimidinediaminehydrochloride;NBI27914HCl;NBI 27914 HYDROCHLORIDE;NBI 27914 >=98% (HPLC);NBI 27914 hydrochlor;4,6-Pyrimidinediamine, 5-chloro-N4-(cyclopropylmethyl)-2-methyl-N4-propyl-N6-(2,4,6-trichlorophenyl)- | | CAS: | 184241-44-9 | | MF: | C18H20Cl4N4 | | MW: | 434.19 | | EINECS: | | | Product Categories: | CRF receptor and related | | Mol File: | 184241-44-9.mol |  |
| | 5-CHLORO-N-(CYCLOPROPYLMETHYL)-2-METHYL-N-PROPYL-N'-(2,4,6-TRICHLOROPHENYL)-4,6-PYRIMIDINEDIAMINE HYDROCHLORIDE Chemical Properties |
| Boiling point | 483.7±45.0 °C(Predicted) | | density | 1.417±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: 16 mg/mL at 60 °C, soluble | | form | solid | | pka | 3.58±0.50(Predicted) | | color | white |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 |
| | 5-CHLORO-N-(CYCLOPROPYLMETHYL)-2-METHYL-N-PROPYL-N'-(2,4,6-TRICHLOROPHENYL)-4,6-PYRIMIDINEDIAMINE HYDROCHLORIDE Usage And Synthesis |
| Uses | NBI 27914 has been used as acorticotropin-releasing hormone receptor (CRHR1) antagonist:
- to study its effects on steroidogenic gene expression in GD15 mouse testis
- to study its effects on amyloid β production
- to study its effects on neurogenic activity of neural stem cells in the adult hippocampus
| | Definition | ChEBI: 5-chloro-N4-(cyclopropylmethyl)-2-methyl-N4-propyl-N6-(2,4,6-trichlorophenyl)pyrimidine-4,6-diamine is a dialkylarylamine and a tertiary amino compound. | | Biological Activity | Selective, non-peptide corticotropin-releasing factor 1 (CRF 1 ) receptor antagonist (K i = 1.7 nM); has no activity at CRF 2 receptors. Blocks behavioral seizures in vivo . | | Biochem/physiol Actions | NBI 27914 is a CRF1 corticotropin-releasing factor receptor antagonist. |
| | 5-CHLORO-N-(CYCLOPROPYLMETHYL)-2-METHYL-N-PROPYL-N'-(2,4,6-TRICHLOROPHENYL)-4,6-PYRIMIDINEDIAMINE HYDROCHLORIDE Preparation Products And Raw materials |
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