| Company Name: |
Fan De(Beijing) Biotechnology Co., Ltd.
|
| Tel: |
15911056312 |
| Email: |
liming@bio-fount.com |
| Products Intro: |
Product Name:2-aminomethyl-4-t-butyl-6-iodophenol
CAS:58456-91-0
Purity:97.0% Package:5mg
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| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:MK-447
CAS:58456-91-0
Package:25mg/RMB 10600
|
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| | 2-aminomethyl-4-t-butyl-6-iodophenol Basic information |
| Product Name: | 2-aminomethyl-4-t-butyl-6-iodophenol | | Synonyms: | 2-aminomethyl-4-t-butyl-6-iodophenol;6-Iodo-2-(aminomethyl)-4-tert-butylphenol;MK-447;2-(aminomethyl)-4-tert-butyl-6-iodophenol;Phenol, 2-(aminomethyl)-4-(1,1-dimethylethyl)-6-iodo- | | CAS: | 58456-91-0 | | MF: | C11H16INO | | MW: | 305.16 | | EINECS: | | | Product Categories: | | | Mol File: | 58456-91-0.mol |  |
| | 2-aminomethyl-4-t-butyl-6-iodophenol Chemical Properties |
| Melting point | 146-146.5 °C (decomp) | | Boiling point | 306.9±42.0 °C(Predicted) | | density | 1.552±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 7.30±0.50(Predicted) |
| | 2-aminomethyl-4-t-butyl-6-iodophenol Usage And Synthesis |
| Uses | MK-447 is a free radical scavenger, also a nonsteroidal antiinflammatory agent, and enhances the formation of the endoperoxide, PGH2, and other prostaglandins. | | in vivo | MK-447 (20 and 50 mg/kg, p.o.) blocks gastric acid secretion in the 4 hour pylorus ligated rats, but shows no effect on gastric secretion of pepsin. MK-447 (5, 10, 20 and 40 mg/kg, p.o.) dose-dependently decreases acid output in dogs[1]. | | IC 50 | PGI2 | | References | [1] Shriver DA, et al. The gastric antisecretory and antiulcer activity of MK-447, an enhancer of prostaglandin synthesis. Life Sci. 1980 Dec 22-29;27(25-26):2483-7. DOI:10.1016/0024-3205(80)90526-3
[2] Harada Y, et al. Acceleration of endogeneous PGI2 generation from isolated rat aortae by MK-447. Jpn J Pharmacol. 1981 Oct;31(5):845-8. DOI:10.1254/jjp.31.845 |
| | 2-aminomethyl-4-t-butyl-6-iodophenol Preparation Products And Raw materials |
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