MK-447
| 中文名称 | MK-447 |
|---|---|
| 中文同义词 | 化合物 T12063 |
| 英文名称 | 2-aminomethyl-4-t-butyl-6-iodophenol |
| 英文同义词 | 2-aminomethyl-4-t-butyl-6-iodophenol;6-Iodo-2-(aminomethyl)-4-tert-butylphenol;MK-447;2-(aminomethyl)-4-tert-butyl-6-iodophenol;Phenol, 2-(aminomethyl)-4-(1,1-dimethylethyl)-6-iodo- |
| CAS号 | 58456-91-0 |
| 分子式 | C11H16INO |
| 分子量 | 305.16 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 58456-91-0.mol |
| 结构式 |  |
MK-447 性质
| 熔点 | 146-146.5 °C (decomp) |
|---|---|
| 沸点 | 306.9±42.0 °C(Predicted) |
| 密度 | 1.552±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 7.30±0.50(Predicted) |
MK-447 是一种自由基清除剂，同时为非甾体类抗炎剂，能够增强 PGH2 等其他前列腺素 (prostaglandin) 的形成。
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PGH 2
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PGI 2
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MK-447 is a free radical scavenger, reduces the accumulation of the endoperoxide, PGG 2 and also enhances the formation of the endoperoxide, PGH 2 , and other prostaglandins. MK-447 (100 μM) increases the amounts of prostaglandin I2 (PGI2). MK-447 also accelerates endogenous PGI2 generation in the isolated rat aorta.
MK-447 (20 and 50 mg/kg, p.o.) blocks gastric acid secretion in the 4 hour pylorus ligated rats, but shows no effect on gastric secretion of pepsin. MK-447 (5, 10, 20 and 40 mg/kg, p.o.) dose-dependently decreases acid output in dogs.