| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
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400-9205774 |
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sales@glpbio.cn |
| Products Intro: |
Product Name:Satratoxin G
CAS:53126-63-9
Purity:>98% Package:1mg;10mg;50mg;100mg;
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| Company Name: |
ChemeGen 中国
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:Satratoxin G
CAS:53126-63-9
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
| Company Name: |
Cayman Chemical Company
|
| Tel: |
(800) 364-9897 |
| Email: |
cayman@caymanchem.com |
| Products Intro: |
Product Name:Satratoxin G
CAS:53126-63-9
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| | satratoxin G Basic information |
| Product Name: | satratoxin G | | Synonyms: | satratoxin G;2',3'-Oxy-2',3'-dihydrosatratoxin H;C028268;Isosatratoxin g;Spiro[10,12:19,22a-dimethano-4H,5H,22aH-oxireno[8,9][1,6,12]trioxacyclooctadecino[3,4-d][1]benzopyran-11(10H),2'-oxirane]-2,14(1aH,19H)-dione, 6,8a,11a,12,21,22-hexahydro-23-hydroxy-19-(1-hydroxyethyl)-7,11a-dimethyl- | | CAS: | 53126-63-9 | | MF: | C29H36O10 | | MW: | 544.59 | | EINECS: | | | Product Categories: | | | Mol File: | 53126-63-9.mol |  |
| | satratoxin G Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble | | form | A crystalline solid |
| | satratoxin G Usage And Synthesis |
| Biological Activity | Satratoxin G is a macrocyclic trichothecene mycotoxin that has been found in S. chartarum.1,2 It induces cleavage of caspase-3 and poly(ADP-ribose) polymerase (PARP) in HL-60 cells when used at a concentration of 40 nM and is cytotoxic to HepG2, Hep-2, Caco-2, A204, U937, and Jurkat cells (IC50s = 2.2-9.7 ng/ml).3,4 Intranasal administration of satratoxin G (500 μg/kg) induces apoptosis of olfactory sensory neurons in olfactory epithelium and ethmoid turbinate expression of the genes encoding IL-1α, IL-1β, IL-6, TNF-α, and MIP-2 in mice.2 Satratoxin G induces lethality in 4 week-old male mice (LD50 = 1.23 mg/kg, i.p.).1 | | References | |1. Yoshizawa, T., Ohtsubo, K., Sasaki, T., et al. Acute toxicities of satratoxins G and H in mice--a histopathological observation with special reference to the liver injury caused by satratoxin G. Proc. Jpn. Assoc. Mycotoxicol. 23, 53-57 (1986).|2. Islam, Z., Harkema, J.R., and Pestka, J.J. Satratoxin G from the black mold Stachybotrys chartarum evokes olfactory sensory neuron loss and inflammation in the murine nose and brain. Environ. Health Perspect. 114(7), 1099-1107 (2006).|3. Nagase, M., Shiota, T., Tsushima, A., et al. Molecular mechanism of satratoxin-induced apoptosis in HL-60 cells: Activation of caspase-8 and caspase-9 is involved in activation of caspase-3. Immunol. Lett. 84(1), 23-27 (2002).|4. Nielsen, C., Casteel, M., Didier, A., et al. Trichothecene-induced cytotoxicity on human cell lines. Mycotoxin Res. 25(2), 77-84 (2009). |
| | satratoxin G Preparation Products And Raw materials |
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