2-羟基乳清酸
| 中文名称 | 2-羟基乳清酸 |
|---|---|
| 中文同义词 | 2-羟基乳清酸;2-羟基油酸;2-羟基乳清酸-D17;2-羟基油酸-D17(Z和E的混合物) |
| 英文名称 | 2-HYDROXYOLEICACID |
| 英文同义词 | 2-HYDROXYOLEICACID;2-Hydroxy Oleic Acid (Mixture of Z and E IsoMers);(9Z)-2-Hydroxy-9-octadecenoic Acid;(Z)-2-Hydroxyoctadec-9-enoic acid;cis-2-Hydroxy-9-octadecenoic Acid;Minerval;α-Hydroxyoleic Acid;(9Z)-2-Hydroxy-9-octadecenoic Acid-d17 |
| CAS号 | 56472-29-8 |
| 分子式 | C18H34O3 |
| 分子量 | 298.46 |
| EINECS号 | |
| 相关类别 | 合成;羟基脂肪酸;Apoptosis;Fatty Acid Derivatives & Lipids;Glycerols;Intermediates & Fine Chemicals;Pharmaceuticals;Protein Kinase Inhibitors and Activators |
| Mol文件 | 56472-29-8.mol |
| 结构式 |  |
2-羟基乳清酸 性质
| 熔点 | 47-50oC |
|---|---|
| 储存条件 | room temp |
| 溶解度 | 二甲基亚砜：>20mg/mL |
| 形态 | 固体 |
| 颜色 | 白色至棕褐色 |
Minerval (2-Hydroxyoleic acid) 是一种合成油酸 (OA) 衍生物，能与质膜结合改变脂质组织。Minerval 具有抗肿瘤作用。
Minerval (25-75 μM; 72 hours) impairs Jurkat cell growth in a time- and concentration-dependent manner, with an IC
50
of ~40 μM.
Minerval (25-50 μM; 72 hours) also induces a marked and concentration-dependent increase in the proteolytic cleavage of PARP, a molecular marker of apoptosis.
Cell Viability Assay
| Cell Line: | Jurkat cells |
| Concentration: | 25 μM, 50 μM, 75 μM |
| Incubation Time: | 24 hours, 48 hours, 72 hours |
| Result: | Impaired Jurkat cell growth in a time- and concentration-dependent manner. |
Western Blot Analysis
| Cell Line: | Jurkat cells |
| Concentration: | 25 μM, 50 μM |
| Incubation Time: | 72 hours |
| Result: | Induced a marked and concentration-dependent increase in the proteolytic cleavage of PARP. |
Minerval markedly and significantly inhibits tumour growth in nude mice infected with Jurkat cells.
| Animal Model: | 6-week-old nude male mice (Jurkat cells xenograft model) |
| Dosage: | 600 mg/kg |
| Administration: | Oral administration; daily; for 21 days |
| Result: | Markedly and significantly inhibited tumour growth. |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-16715 | 2-羟基乳清酸 Acumapimod | 56472-29-8 | 5mg | 1000元 |
| 2024/01/25 | HY-16715 | 2-羟基乳清酸 Acumapimod | 56472-29-8 | 10mM * 1mLin DMSO | 1100元 |
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