1-【4-(二苯甲基)-1-哌嗪基】-3,3-二苯基-1-丙酮
| 中文名称 | 1-【4-(二苯甲基)-1-哌嗪基】-3,3-二苯基-1-丙酮 |
|---|---|
| 中文同义词 | 1-【4-(二苯甲基)-1-哌嗪基】-3,3-二苯基-1-丙酮;1-(二苯基甲基)-4-(1-氧代-3,3-二苯基丙基)哌嗪;1-[4-(二苯基甲基)-1-哌嗪]-3,3-二苯基-1-丙酮;NP118809,N 型钙通道 (N-TYPE CALCIUM CHANNEL) 阻滞剂 |
| 英文名称 | 1-[4-(DiphenylMethyl)-1-piperazinyl]-3,3-diphenyl-1-propanone |
| 英文同义词 | 1-[4-(DiphenylMethyl)-1-piperazinyl]-3,3-diphenyl-1-propanone;1-(DiphenylMethyl)-4-(1-oxo-3,3-diphenylpropyl)piperazine;39-1B4;NP 118809;Z160;Piperazine, 1-(diphenylmethyl)-4-(1-oxo-3,3-diphenylpropyl)-;1-Propanone, 1-[4-(diphenylmethyl)-1-piperazinyl]-3,3-diphenyl-;NP118809 (39-1B4 |
| CAS号 | 41332-24-5 |
| 分子式 | C32H32N2O |
| 分子量 | 460.61 |
| EINECS号 | |
| 相关类别 | 离子通道;膜转运;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol文件 | 41332-24-5.mol |
| 结构式 |  |
1-【4-(二苯甲基)-1-哌嗪基】-3,3-二苯基-1-丙酮 性质
| 沸点 | 618.9±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.142±0.06 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,Room Temperature |
| 溶解度 | DMSO：50 mg/mL（108.55 mM；需要超声波）H2O：< 0.1 mg/mL（不溶） |
| 形态 | 粉末 |
| 酸度系数(pKa) | 5.99±0.10(Predicted) |
|
N-Type Ca 2+ Channel 0.11 μM (IC 50 ) |
L-type calcium channel 12.2 μM (IC 50 ) |
NP118809 is a potent N-type calcium channel blocker, with an IC 50 of 0.11 μM; also inhibits L-type calcium channel with an IC 50 of 12.2 μM. NP118809 inhibits the hERG potassium channel in HEK cells, with an IC 50 of 7.4 μM.
NP118809 (25 mg/kg, i.p.) shows significant analgesic activity in the phase IIA portions of the rat formalin model. NP118809 (30 mg/kg, p.o.) results in 80.3% inhibition of mechanical allodynia and 96.3% inhibition of thermal hyperalgesia in the rat spinal nerve ligation model.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-14462 | 1-【4-(二苯甲基)-1-哌嗪基】-3,3-二苯基-1-丙酮 NP118809 | 41332-24-5 | 100mg | 744元 |
| 2024/01/25 | HY-14462 | 1-【4-(二苯甲基)-1-哌嗪基】-3,3-二苯基-1-丙酮 NP118809 | 41332-24-5 | 10mM * 1mLin DMSO | 818元 |