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Product Name:Merck-22-6
CAS:12847-42-4
Purity:>98% Package:1Mg;5Mg;10Mg;50Mg;100Mg
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Merck-22-6 manufacturers
- Merck-22-6
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- $1520.00 / 25mg
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2025-10-27
- CAS:612847-42-4
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | Merck-22-6 Basic information |
| Product Name: | Merck-22-6 | | Synonyms: | Merck-22-6;Merck-22-6 (KRC380);Merck-22-6 >=95%;6-Quinoxalinecarboxamide, N-[2-(diethylamino)ethyl]-3-[4-[[4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]methyl]phenyl]-2-phenyl-;N-(2-(diethylamino)ethyl)-3-(4-((4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)methyl)phenyl)-2-phenylquinoxaline-6-carboxamide;Akt1/Akt2-IN-2;N-[2-(diethylamino)ethyl]-3-(4-{[4-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1-yl)piperidin-1-yl]methyl}phenyl)-2-phenylquinoxaline-6-carboxamide | | CAS: | 612847-42-4 | | MF: | C40H43N7O2 | | MW: | 653.82 | | EINECS: | | | Product Categories: | | | Mol File: | 612847-42-4.mol |  |
| | Merck-22-6 Chemical Properties |
| form | Solid | | color | Off-white to light yellow |
| | Merck-22-6 Usage And Synthesis |
| Description | Merck-22-6 is an allosteric dual Akt1, Akt2 inhibitor. | | Uses | Akt1/Akt2-IN-2 (compound 7) is an allosteric dual Akt1 and Akt2 inhibitor (IC50=138 nM and 212 nM, respectively). Akt1/Akt2-IN-2 increases activity of caspase-3, and inhibits viability of a number of tumor cells[1]. | | IC 50 | Akt1: 138 nM (IC50); Akt2: 212 nM (IC50); Akt3: 7.2 mM (IC50); Caspase-3 | | References | [1] Zhao Z, et al. Development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved physical properties and cell activity. Bioorg Med Chem Lett. 2008 Jan 1;18(1):49-53. DOI:10.1016/j.bmcl.2007.11.015 |
| | Merck-22-6 Preparation Products And Raw materials |
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