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| Product Name: | NG-25 | | Synonyms: | N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide;3-((1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)-N-(4-((4-ethylpiperazin-1-yl)methyl)-3v-(trifluoromethyl)phenyl)-4-methylbenzamide;NG-25;HG-7-92-01
(NG 25);N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide;NG 25; NG-25;Benzamide, N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-;NG-25 ISO 9001：2015 REACH | | CAS: | 1315355-93-1 | | MF: | C29H30F3N5O2 | | MW: | 537.58 | | EINECS: | | | Product Categories: | Smad;TGF-beta;TGF-beta/Smad | | Mol File: | 1315355-93-1.mol |  |
| | NG-25 Chemical Properties |
| density | 1.313±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | Soluble in DMSO | | form | powder | | pka | 12.91±0.70(Predicted) | | color | white to beige |
| RIDADR | UN 2811 6.1 / PGIII |
| | NG-25 Usage And Synthesis |
| Uses | NG 25 inhibits TGF-beta-activated kinase 1 (TAK1). It also inhibits LYN, mitogen-activated protein kinase (MAP4K2) and Abl kinase activity. | | Biochem/physiol Actions | NG25 is potent multiple kinase inhibitor belonging to type II kinase inhibitors class that binds to kinase ATP binding pocket at not ready to catalyze conformation. NG25 is used as a potent dual inhibitor of TAK1 (TGFβ-Activated Kinase 1, MAP3K7) and MAP4K2 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2; GCK) kinases. NG25 inhibits the activation of IKKa/IKKb and prevents the secretion of type 1 IFNs by TLR2 and TLR9 agonist. | | storage | Store at -20°C |
| | NG-25 Preparation Products And Raw materials |
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