| Company Name: |
Tongchuang Pharma(Suzhou). Co., Ltd.
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| Tel: |
0512-63263366 18912765016 |
| Email: |
tongtf110@sina.com |
| Products Intro: |
Product Name:5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid
CAS:1052114-81-4
Package:5g
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| Company Name: |
Hangzhou Trylead Chemical Technology Co.,LTD
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| Tel: |
0571-87086220 13516718938 |
| Email: |
zyf@trylead-chem.com |
| Products Intro: |
Product Name:3-Pyridinecarboxylic acid, 5-(4-fluorophenyl)-1,4-dihydro-4-oxo-
CAS:1052114-81-4
Purity:98% Package:5g,10g,25g
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| Company Name: |
Shanghai Send Pharmaceutical Technology Co., Ltd.
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| Tel: |
021-58088081 Q2635253576 |
| Email: |
hailey@shsendpharm.com |
| Products Intro: |
Product Name:5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid
CAS:1052114-81-4
Purity:98% Package:1g/;5g/;50g/;100g/;1kg/;5kg/
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| Company Name: |
Shanghai Brain Biotechnology Co., Ltd.
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| Tel: |
13564638271 |
| Email: |
shhjiang1977@163.com |
| Products Intro: |
Product Name:5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid
CAS:1052114-81-4
Purity:98% HPLC and HNMR Package:5g;10g；25g;50g；100g;250g；500g;1000g
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| | 5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid Basic information |
| | 5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid Chemical Properties |
| Boiling point | 423.3±45.0 °C(Predicted) | | density | 1.437±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | -0.34±0.20(Predicted) | | Appearance | White to light yellow Solid |
| | 5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid Usage And Synthesis |
| Synthesis | Example A8: Example A7 (0.750 g, 2.87 mmol) was suspended in 3 M NaOH aqueous solution (7.5 mL, 22.50 mmol) and heated to reflux at 100 °C for 1.5 hrs. Upon completion of the reaction, the mixture was cooled to room temperature and slowly acidified to pH 2 with 3 M aqueous HCl. The precipitated white solid was collected by vacuum filtration and washed with deionized water and dried to afford 5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid (669 mg, 100% yield). The product was analyzed by mass spectrometry (ESI), m/z: 234.1 ([M + H]+). | | References | [1] Patent: WO2014/145004, 2014, A1. Location in patent: Paragraph 0111
[2] Journal of Medicinal Chemistry, 2008, vol. 51, # 17, p. 5330 - 5341
[3] Patent: WO2009/94417, 2009, A1. Location in patent: Page/Page column 28; 35-36
[4] Patent: WO2014/713, 2014, A1. Location in patent: Page/Page column 38 |
| | 5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid Preparation Products And Raw materials |
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