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| | 2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid hydroxyamide Basic information |
| Product Name: | 2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid hydroxyamide | | Synonyms: | 2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid hydroxyamide;ACY-738;N-Hydroxy-2-[(1-phenylcyclopropyl)amino]-5-pyrimidinecarboxamide;ACY 738; ACY738;2-(1-phenylcyclopropylamino)-N-hydroxypyrimidine-5-carboxamide;ACY738;ACY-738;ACY 738;CS-2244;5-Pyrimidinecarboxamide, N-hydroxy-2-[(1-phenylcyclopropyl)amino]- | | CAS: | 1375465-91-0 | | MF: | C14H14N4O2 | | MW: | 270.29 | | EINECS: | | | Product Categories: | | | Mol File: | 1375465-91-0.mol |  |
| | 2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid hydroxyamide Chemical Properties |
| density | 1.433±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO:32.0(Max Conc. mg/mL);118.39(Max Conc. mM) | | form | A crystalline solid | | pka | 7.75±0.10(Predicted) |
| | 2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid hydroxyamide Usage And Synthesis |
| Description | ACY-738 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 1.7 nM). It is selective for HDAC6 over HDAC1-3 (IC50s = 94, 128, and 218 nM, respectively). ACY-738 (5 mg/kg) increases acetylation of α-tubulin in mouse brain. It increases exploratory activity in a novel open-field test and reduces immobility time in a tail suspension test in wild-type, but not neural cell-selective HDAC6 knockout, mice when administered at a dose of 50 mg/kg, indicating anxiolytic and antidepressant-like activity, respectively. ACY-738 (100 mg/kg in the diet) attenuates decreases in caudal nerve sensory nerve action potential (SNAP) amplitude and increases in hind paw mechanical hypersensitivity in a mouse model of peripheral neuropathy induced by vincristine . It decreases hepatorenal cystogenesis in a rat model of polycystic liver disease when administered at a dose of 30 mg/kg. |
| | 2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid hydroxyamide Preparation Products And Raw materials |
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