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Product Name:DH 97
CAS:220339-00-4
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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DH 97 manufacturers
- DH97
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- $2500.00 / 100mg
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2025-10-27
- CAS:220339-00-4
- Min. Order:
- Purity:
- Supply Ability: 10g
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| Product Name: | DH 97 | | Synonyms: | DH97,DH-97;Pentanamide, N-[2-[2-(phenylmethyl)-1H-indol-3-yl]ethyl]- | | CAS: | 220339-00-4 | | MF: | C22H26N2O | | MW: | 334.45 | | EINECS: | | | Product Categories: | | | Mol File: | 220339-00-4.mol |  |
| | DH 97 Chemical Properties |
| Boiling point | 580.1±38.0 °C(Predicted) | | density | 1.105±0.06 g/cm3(Predicted) | | storage temp. | Store at RT | | solubility | Soluble to 100 mM in DMSO | | form | Powder | | pka | 16.36±0.46(Predicted) |
| | DH 97 Usage And Synthesis |
| Description | A relatively potent MT2 melatonin receptor antagonist (pKi value = 8.03), displaying 89- and 229-fold selectivity over MT1 and GPR50 (melatonin-related orphan receptor) respectively. | | Uses | N-Pentanoyl 2-benzyltryptamine is a potent and selective antagonist of MT2 melatonin receptor, with a pKi of 8.03 for human MT2. N-Pentanoyl 2-benzyltryptamine shows 89- and 229-fold selectivity for human MT2 over human mt1 and Xenopus mel1c receptor subtypes. N-Pentanoyl 2-benzyltryptamine can inhibit melatonin-induced enhancement of electrically-evoked responses[1][2]. | | Definition | ChEBI: N-[2-[2-(phenylmethyl)-1H-indol-3-yl]ethyl]pentanamide is a member of indoles. | | IC 50 | MT2: 8.03 (pKi); MT1: 6.08 (pKi) | | storage | Store at RT | | References | [1] Teh MT, et, al. Comparison of the structure-activity relationships of melatonin receptor agonists and antagonists: lengthening the N-acyl side-chain has differing effects on potency on Xenopus melanophores. Naunyn Schmiedebergs Arch Pharmacol. 1998 Nov;358(5):522-8. DOI:10.1007/pl00005288
[2] Ting KN, et, al. Molecular and pharmacological evidence for MT1 melatonin receptor subtype in the tail artery of juvenile Wistar rats. Br J Pharmacol. 1999 Jun;127(4):987-95. DOI:10.1038/sj.bjp.0702612 |
| | DH 97 Preparation Products And Raw materials |
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