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Neocryptotanshinone manufacturers
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| | Neocryptotanshinone Basic information |
| Product Name: | Neocryptotanshinone | | Synonyms: | Neocryptotanshinone;5,6,7,8-Tetrahydro-3-hydroxy-2-[(1R)-2-hydroxy-1-methylethyl]-8,8-dimethyl-1,4-phenanthrenedione;1,4-Phenanthrenedione, 5,6,7,8-tetrahydro-3-hydroxy-2-[(1R)-2-hydroxy-1-methylethyl]-8,8-dimethyl-;(R)-3-Hydroxy-2-(1-hydroxypropan-2-yl)-8,8-dimethyl-5,6,7,8-tetrahydrophenanthrene-1,4-dione | | CAS: | 109664-02-0 | | MF: | C19H22O4 | | MW: | 314.38 | | EINECS: | | | Product Categories: | | | Mol File: | 109664-02-0.mol |  |
| | Neocryptotanshinone Chemical Properties |
| Boiling point | 517.1±50.0 °C(Predicted) | | density | 1+-.0.06 g/cm3(Predicted) | | storage temp. | 4°C, protect from light | | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | form | Powder | | pka | 4.50±1.00(Predicted) | | color | Light yellow to yellow | | InChI | InChI=1S/C19H22O4/c1-10(9-20)14-16(21)12-6-7-13-11(5-4-8-19(13,2)3)15(12)18(23)17(14)22/h6-7,10,20,22H,4-5,8-9H2,1-3H3/t10-/m0/s1 | | InChIKey | PKEGICXVZMKJPR-JTQLQIEISA-N | | SMILES | C1(=O)C2=C(C3=C(C=C2)C(C)(C)CCC3)C(=O)C(O)=C1[C@@H](C)CO |
| | Neocryptotanshinone Usage And Synthesis |
| Uses | Neocryptotanshinone, a fatty diterpenoids from Salvia Miltiorrhiza, inhibits lipopolysaccharide-induced inflammation by suppression of NF-κB and iNOS signaling pathways[1][2]. | | in vivo | Neocryptotanshinone causes reversals of decreased pain thresholds induced by MSU treatment after 30, 60, and 120 min S. miltiorrhiza Bunge extract treatment (contains single active components)[3]. | Animal Model: | MSU-induced pain model in male ICR mice (weighing 20-25 g)[2] | | Dosage: | 10, 25, 50 or 100 mg/kg | | Administration: | Oral gavage; for 30, 60, 120 min | | Result: | Inhibited inflammatory symptoms and nociceptive behaviors in a dose-dependent manner. |
| | IC 50 | iNOS | | References | [1] Chuanhong Wu, et al. Neocryptotanshinone Inhibits Lipopolysaccharide-Induced Inflammation in RAW264.7 Macrophages by Suppression of NF-κB and iNOS Signaling Pathways. Acta Pharm Sin B. 2015 Jul;5(4):323-9. DOI:10.1016/j.apsb.2015.01.010
[2] H C Lin, et al. Two New Fatty Diterpenoids From Salvia Miltiorrhiza. J Nat Prod. 2001 May;64(5):648-50. DOI:10.1021/np000345v
[3] FENG Jinghui, et al. Effects of Salvia miltiorrhiza Bunge extract and its single components on monosodium urate-induced pain in vivo and lipopolysaccharide-induced inflammation in vitro. J Tradit Chin Med. 2021. 41(2): 219-226. PMID:33825401 |
| | Neocryptotanshinone Preparation Products And Raw materials |
| Raw materials | 2H-9,4a-(Epoxymethano)phenanthren-12-one, 1,3,4,9,10,10a-hexahydro-5,6-dihydroxy-7-[(1R)-2-hydroxy-1-methylethyl]-1,1-dimethyl-, (4aR,9S,10aS)--->1-Naphthalenol, 5,6,7,8-tetrahydro-5,5-dimethyl--->1,2,3,4-tetrahydro-5-Methoxy-1,1-diMethylnaphthalene-->Cryptotanshinone-->5-Bromo-2-methyl-2-pentene-->2-Bromoanisole-->Anisole |
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