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| | 2-Propenoic acid, 3,3'-(1,3-phenylene)bis- Basic information |
| Product Name: | 2-Propenoic acid, 3,3'-(1,3-phenylene)bis- | | Synonyms: | 2-Propenoic acid, 3,3'-(1,3-phenylene)bis-;TC AQP1 1;TC-AQP-1-1,TCAQP11,TC AQP1 1;2-Propenoic acid, 3,3'-(1,3-phenylene)bis-;m-Benzenediacrylic acid;m-Phenylenediacrylic acid | | CAS: | 37710-81-9 | | MF: | C12H10O4 | | MW: | 218.21 | | EINECS: | | | Product Categories: | | | Mol File: | 37710-81-9.mol |  |
| | 2-Propenoic acid, 3,3'-(1,3-phenylene)bis- Chemical Properties |
| Boiling point | 458.7±33.0 °C(Predicted) | | density | 1.358±0.06 g/cm3(Predicted) | | storage temp. | RT | | solubility | Soluble in DMSO (up to 25 mg/ml). | | pka | 4.07±0.10(Predicted) | | form | solid | | color | White | | Stability: | Stable for 1 year from date of pruchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| | 2-Propenoic acid, 3,3'-(1,3-phenylene)bis- Usage And Synthesis |
| Description | CVPA (37710-81-9) is an aquaporin-1 inhibitor (IC50 = 8.1 μM) discovered by molecular docking against the extracellular domain of human aquaporin-1 followed by experimental testing in a Xenopus oocyte swelling assay.1 | | Uses | TC AQP1 1 is a human aquaoporin-1 (hAQP1) selective inhibitor and is considered to have therapeutic potential towards the potential treatment of glaucoma, brain edema, inflammatory pain and certain types of cancer. | | storage | Store at +4°C | | References | 1) Seeliger et al. (2012), Discovery of novel human aquaporin-1 blockers; ACS Chem. Biol., 8 249 |
| | 2-Propenoic acid, 3,3'-(1,3-phenylene)bis- Preparation Products And Raw materials |
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