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3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE

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3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:NSC 693868
CAS:40254-90-8
Package:10 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Hangzhou MolCore BioPharmatech Co.,Ltd.
Tel: +86-057181025280; +8617767106207
Email: sales@molcore.com
Products Intro: Product Name:NSC693868
CAS:40254-90-8
Purity:NLT 98% Remarks:MC553274
Company Name: ZHEJIANG JIUZHOU CHEM CO., LTD
Tel: +86-0576225566889 +86-13454675544
Email: admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com
Products Intro: Product Name:3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE
CAS:40254-90-8
Package:1KG
Company Name: Aladdin Scientific
Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:Cdk1/5 Inhibitor inhibitor
CAS:40254-90-8
Purity:>=95% Package:$57.9/1mg;$190.9/5mg;$342.9/10mg;Bulk package Remarks:95%
Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
Tel: 821-50328103-801 18930552037
Email: 3bsc@sina.com
Products Intro: Product Name:NSC 693868;1H-Pyrazolo[3,4-b]quinoxalin-3-aMine
CAS:40254-90-8
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE Basic information
Product Name:3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE
Synonyms:1H-PYRAZOLO[3,4-B]QUINOXALIN-3-AMINE;3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE;NSC 693868;1H-Pyrazolo[3,4-b]quinoxalin-3-amine(9CI);3-Aminopyrazolo[3,4-b]quinoxaline;1H-Pyrazolo[3,4-b]quinoxalin-3-ylamine;Cdk1/5 Inhibitor - CAS 40254-90-8 - Calbiochem;Brimonidine Impurity 8
CAS:40254-90-8
MF:C9H7N5
MW:185.19
EINECS:
Product Categories:Protein Kinase;PIPERIDINE
Mol File:40254-90-8.mol
3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE Structure
3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE Chemical Properties
Melting point 292-293℃ (ethanol )
Boiling point 522.8±45.0 °C(Predicted)
density 1.570±0.06 g/cm3(Predicted)
storage temp. Store at +4°C
solubility Soluble to 100 mM in DMSO
form Red solid
pka7.40±0.50(Predicted)
Safety Information
Hazard Codes T
Risk Statements 25
Safety Statements 45
RIDADR UN 2811 6.1 / PGIII
MSDS Information
3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE Usage And Synthesis
DescriptionCyclin-dependent kinases (Cdks) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. Cdk1/5 Inhibitor is a pyrazolo [3,4-b] quioxaline that inhibits Cdk1/cyclin B and Cdk5/p25 (IC50s = 600 and 400 nM, respectively). It less potently inhibits GSK3β (IC50 = 1 μM) and does not block Cdc25 activity. This compound is used to help define the roles of Cdk1 and Cdk5 in various signaling pathways.
UsesCyclin-dependent kinases (CDKs) are protein kinases and involved with the regulation of the cell cycle. NSC 693868 is an inhibitor of Cdk1/cyclin B and Cdk5/p25.?Small molecules that target these protein kinases are valuable tools for investigating cellular signaling pathways and are potential therapeutic agents.
DefinitionChEBI: 2H-pyrazolo[4,3-b]quinoxalin-3-amine is a quinoxaline derivative.
Biological ActivityInhibitor of cyclin-dependent kinases (cdks) and glycogen synthase kinase-3 (GSK-3). IC 50 values are 0.6, 0.4 and 1 μ M for cdk1/cyclin B, cdk5/p25 and GSK-3 respectively.
3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE Preparation Products And Raw materials
Raw materials3-Chloroquinoxaline-2-carbonitrile
Tag:3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE(40254-90-8) Related Product Information
Brimonidine Impurity 6 Sodium Salt 5-Bromoquinazolin-6-ylthiourea 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine BriMonidine-2,3-dione Brimonidine Impurity 7 Brimonidine Related Impurity 3 1H-PYRAZOLO[3,4-B]PYRAZIN-3-AMINE 4,7-DIAZA-1H-INDAZOLE 3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE