ChemicalBook > Product Catalog >Flavors and fragrances >Synthetic fragrances >Macrocyclic musks >Macrocyclic spices >Cyclopentadecanone

Cyclopentadecanone

Cyclopentadecanone Suppliers list
Company Name: Suzhou C1 Technology Co.,Ltd
Tel: 13505321808
Email: fischer@qdfinechem.com
Products Intro: Product Name:Cyclopentadecanone
CAS:502-72-7
Purity:99%(GC and H NMR) Package:kg
Company Name: career henan chemical co
Tel: +86-0371-86658258
Email: sales@coreychem.com
Products Intro: Product Name:Cyclopentadecanone
CAS:502-72-7
Purity:98% Package:1KG;1USD
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 86-18871470254
Email: linda@hubeijusheng.com
Products Intro: Product Name:Cyclopentadecanone
CAS:502-72-7
Purity:99% Package:5KG;1KG Remarks:C15H28O
Company Name: Hebei Guanlang Biotechnology Co., Ltd.
Tel: +86-19930503282 +86-19930503282
Email: alice@crovellbio.com
Products Intro: Product Name:Cyclopentadecanone
CAS:502-72-7
Purity:99% Package:1PCS;10USD
Company Name: Hubei xin bonus chemical co. LTD
Tel: 86-13657291602
Email: linda@hubeijusheng.com
Products Intro: Product Name:Cyclopentadecanone
CAS:502-72-7
Purity:0.99 Package:5KG;1KG

Cyclopentadecanone manufacturers

  • Cyclopentadecanone
  • $10.00 / 1PCS
  • 2021-03-31
  • CAS:502-72-7
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 10 mt
  • Cyclopentadecanone
  • $1.00 / 1KG
  • 2020-03-16
  • CAS:502-72-7
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 50 tons
  • Cyclopentadecanone
  • $1.00 / 1KG
  • 2019-07-06
  • CAS:502-72-7
  • Min. Order: 1KG
  • Purity: 98%
  • Supply Ability: 100KG
Cyclopentadecanone Basic information
Product Name:Cyclopentadecanone
Synonyms:Cyclopentadecanone, 96% 5GR;Normuscon;NORMUSCONE;OXOCYCLOPENTADECANE;MUSK 15;CYCLOPENTADECANONE;CYCLOPENTADECONE;EXALTONE
CAS:502-72-7
MF:C15H28O
MW:224.38
EINECS:207-951-2
Product Categories:C15 to C38;Carbonyl Compounds;Ketones;Building Blocks;C15 to C38;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
Mol File:502-72-7.mol
Cyclopentadecanone Structure
Cyclopentadecanone Chemical Properties
Melting point 63-65 °C (lit.)
Boiling point 120 °C/0.3 mmHg (lit.)
density 0.897 g/mL at 25 °C (lit.)
refractive index 1.4637 (estimate)
Fp 120°C/0.3mm
storage temp. Sealed in dry,Room Temperature
color Colourless crystal needles.
BRN 1618444
CAS DataBase Reference502-72-7(CAS DataBase Reference)
NIST Chemistry ReferenceCyclopentadecanone(502-72-7)
EPA Substance Registry SystemCyclopentadecanone (502-72-7)
Safety Information
Safety Statements 22-24/25
WGK Germany 2
RTECS GY0900000
TSCA Yes
HS Code 29142900
MSDS Information
ProviderLanguage
Cyclopentadecanone English
SigmaAldrich English
ACROS English
ALFA English
Cyclopentadecanone Usage And Synthesis
Chemical PropertiesWHITE CRYSTALLINE POWDER
Chemical PropertiesCyclopentadecanone is a musk fragrance found in the scent gland of the male civet cat.
A number of syntheses have been developed for its manufacture [260]. Among these, the so-called Story procedure is the only route that has the potential to make cyclopentadecanone available on a larger scale, but due to the handling of hydroperoxides, the process is difficult to manage.
The process starts from tricyclohexylidene triperoxide, which is obtained by oxidation of cyclohexanone with hydrogen peroxide. Pyrolysis leads to a mixture of 1,16-hexadecanolide and cyclopentadecane. The latter is oxidized by oxygen under boric acid catalysis to cyclopentadecanol, which is subsequently oxidized to cyclopentadecanone.
Due to the availability of long-chained aliphatic dicarboxylic acids by biotechnological processes, a Dieckmann condensation reaction may also possibly be a useful route to produce this macrocyclic ketone.
Cyclopentadecanone is used in fine fragrances:
OccurrenceReported to be found in the scent glands of the Louisiana muskrat Ondatra zibethicus rivalicius (Guenther, 1949).
UsesCyclopentadecanone is the main odoriferous component of musk.
PreparationBy the cyclization of dinitriles in high dilution (Bedoukian. 1967).
Synthesis Reference(s)Chemistry Letters, 7, p. 1283, 1978
The Journal of Organic Chemistry, 36, p. 3266, 1971 DOI: 10.1021/jo00821a003
Toxicity evaluationBoth the acute oral LD50 value in rats and the acute dermal LD50 value in rabbits exceeded 5 g/kg (Moreno. 1975). The acute ip LD100 of cyclopentadecanone was not reached but was estimated to be >35mmol/kg for mice; an ip dose of 11-25 mmol/kg caused no deaths in 24 hr and one of 8-92 mmol/kg caused no deaths in 4 days (the length of the study). An oral dose of ≥45 mmol/kg caused no deaths in mice. Intense agitation accompanied by catatonia of the tail was caused by low doses of cyclopentadecanone; gross examination of the mice revealed no specific pathology but occasionally degenerative hepatitis, proximal tubular nephritis and, rarely, pancreatic necrosis were found following dosing with cycloalkanones (Caujolle & Caujolle, 1965).
MetabolismKetones are not readily metabolized, although most of them probably undergo appreciable reduction to the corresponding secondary alcohols, which are excreted in the urine as glucuronic acid conjugates (Williams, 1959). Cyclopentadecanone was hydroxylated in cultures of four steroid-hydroxylating fungi (Calonectria decora, Rhizopus nigricans, Daedalea rufescens and Ophiobolus herpotrichus), but was not affected by Aspergillus ochraceus. Initial attack occurred at the most remote carbon atom, with yields of up to 26% of 8-hydroxycyclopentadecanone, plus dihydroxy compounds and more polar products (Ashton, Bailey & Jones, 1974).
Purification MethodsSubliming Exaltone is better than crystallising it from aqueous EtOH for purification. The semicarbazone has m 186-187o. [Stevens & Erickson J Am Chem Soc 64 146 1942, Mathur et al. J Chem Soc 3505 1963, Biens & Hess Helv Chim Acta 71 1704 1988, Beilstein 7 III 203, 7 IV 118.]
Cyclopentadecanone Preparation Products And Raw materials
Preparation ProductsMuscone-->Cyclopentadecanone, 2-hydroxy
Tag:Cyclopentadecanone(502-72-7) Related Product Information
15-oxosteviol Ketolyoniol A EFFUSANIN A AMETHYSTOIDIN A 3,11-DIACETOXY-13-HYDROXY-16-KAUREN-15-ONE ISOSTEVIOL BARBININE ALBOPILOSIN A ACETATE Muscone kamebakaurin songorine lasiokaurin EFFUSANIN E scopadulcic acid B excisanin A ALBOPILOSIN A 14-DEHYDROBROWNIINE METHYL-2-PYRROLIDONE