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ShangHai Caerulum Pharma Discovery Co., Ltd.
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18149758185 |
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sales-cpd@caerulumpharma.com |
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Product Name:Tauro-β-muricholic Acid (sodium salt)
CAS:145022-92-0
Purity:98% Package:1g;10g;100g
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| Company Name: |
BOC Sciences
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16314854226 |
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info@bocsci.com |
| Products Intro: |
Product Name:Tauro-β-muricholic acid sodium salt
CAS:145022-92-0
Purity:95% Package:1G;10G;100G
|
| Company Name: |
Shanghai EFE Biological Technology Co., Ltd.
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| Tel: |
021-65675885 18964387627 |
| Email: |
info@efebio.com |
| Products Intro: |
Product Name:Tauro-β-muricholic Acid (sodium salt)
CAS:145022-92-0
Purity:95% Package:500μg;1mg;5mg
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Tauro--muricholic Acid (sodium salt) manufacturers
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| | Tauro--muricholic Acid (sodium salt) Basic information |
| Product Name: | Tauro--muricholic Acid (sodium salt) | | Synonyms: | Tauro-β-muricholic acid sodium;T-βMCA sodium;Tauro-β-muricholic Acid sodium salt;2-[[(3α,5β,6β,7β)-3,6,7-trihydroxy-24-oxocholan-24-yl]amino]-ethanesulfonicacid,monosodiumsalt;Tauro-β-Muricholic Acid-[d5] Sodium Salt | | CAS: | 145022-92-0 | | MF: | C26H46NNaO7S | | MW: | 539.7 | | EINECS: | | | Product Categories: | | | Mol File: | 145022-92-0.mol |  |
| | Tauro--muricholic Acid (sodium salt) Chemical Properties |
| Melting point | 120-125oC | | storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere | | solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) | | form | Solid | | color | White to Pale Beige | | Stability: | Hygroscopic |
| | Tauro--muricholic Acid (sodium salt) Usage And Synthesis |
| Description | Tauro-β-muricholic acid (TβMCA) is a competitive and reversible antagonist of the farnesoid X receptor (FXR; IC50 = 40 μM) and a taurine-conjugated form of the murine-specific primary bile acid β-muricholic acid . TβMCA accumulates in germ-free mice under normal conditions but is reduced after colonization with feces from a human donor. TβMCA is increased in the intestines of mice resistant to high-fat diet-induced obesity, fatty liver, and diabetes. | | Uses | Tauro-β-muricholic Acid Sodium Salt is the salt form of Tauro-α-muricholic Acid which is a bile acid released by the liver and is typically used in cholestasis studies. | | in vivo | T-βMCA sodium (400 mg/kg; i.g.; twice a week; for 6 weeks) can effectively recapitulate the ability of HFD to promote CRC progression[3].
T-βMCA sodium treatment also significantly increases levels of serum cytokines, including IFN-γ, IL-6, and IL-17[3].
| Animal Model: | APCmin/+ mice[3] | | Dosage: | 400 mg/kg | | Administration: | Oral gavage; twice a week; for 6 weeks | | Result: | Markedly decreased intestinal integrity and accelerated tumor growth in the intestine and colon. |
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| | Tauro--muricholic Acid (sodium salt) Preparation Products And Raw materials |
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