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ChemicalBook Optimization Suppliers |
| 名前: |
Energy Chemical |
| 電話番号: |
021-021-58432009 400-005-6266 |
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sales8178@energy-chemical.com |
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| 融点 | 84-86?C | | 貯蔵温度 | Sealed in dry,2-8°C | | 溶解性 | H2O: soluble | | 外見 | Solid | | 色 | White to Off-White |
| | ペントキシベリンくえん酸塩 Usage And Synthesis |
| 外観 | 白色～ほとんど白色、結晶～粉末 | | 溶解性 | 水に可溶。 | | 用途 | シグマ1 受容体選択的アゴニ
ストです。鎮咳作用を示します。 | | 効能 | 鎮咳薬 | | 化学的特性 | White to Off-White Solid | | Originator | Asthma ,Nichiiko | | 使用 | Sigma receptor agonist | | 使用 | antibacterial, antiproliferative | | 使用 | An over-the-counter cough suppressant. | | 定義 | ChEBI: Carbetapentane citrate is a carbonyl compound. | | Manufacturing Process | 1-Phenylcyclopentane carbonitrile was obtained by treatment of phenylacetonitrile with sodium amide and 1,4-dibrombutane.
1-Phenyl-1-cyclopentane carboxylic acid was produced in the result of reaction of 1-phenylcyclopentane carbonitrile with sulfuric acid.
1-Phenyl-1-cyclopentanecarbonyl chloride was obtained by treatment of 1phenyl-1-cyclopentane carboxylic acid with thionyl chloride.
A mixture of 0.5 mol of 1-phenyl-1-cyclopentanecarbonyl chloride and of 0.5 mol of 2-(2-diethylaminoethoxy)ethanol (herein-after referred to as the amino alcohol) in 300 ml of toluene is heated under reflux for 20 h. The mixture is thereafter made alkaline by means of an aqueous solution of caustic soda and decanted; the toluenic layer is washed with water and concentrated in vacuo. The residue is distilled under high vacuum. After two fractional distillations, the 2-(2-diethylaminoethoxy)ethyl 1-phenylcyclopentane-carboxylate is obtained, in 85% yield. Boiling point 164°C/0.1 mm. Hg. | | brand name | Toclase (Pfizer). | | Therapeutic Function | Antitussive | | 生物活性 | A selective ligand for the σ 1 -site. |
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