1,2-二油酰-SN-甘油-3-磷酰乙醇胺
| 中文名称 | 1,2-二油酰-SN-甘油-3-磷酰乙醇胺 |
|---|---|
| 中文同义词 | 1,2-二油酰基-SN-丙三基-3-磷脂酰乙醇胺;1,2-二油酰基-SN-丙三基-3-磷脂酰乙醇胺;二油酰基 L-Α-磷脂酰乙醇胺;1,2-二油酰-SN-甘油-3-磷酸乙醇胺;二油酰基磷脂酰乙醇胺;1,2-二油酰甘油-3-磷酸乙醇胺;1,2-二油酰-SN-甘油-3-磷酰乙醇胺;DIACYLPHOSPHATIDYLETHANOLAMINE |
| 英文名称 | 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine |
| 英文同义词 | 3-SN-PHOSPHATIDYLETHANOLAMINE, 1,2-DIDEOYL;1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE;1,2-DI([CIS]-9-OCTADECENOYL)-SN-GLYCERO-3-PHOSPHOETHANOLAMINE;18:1 PE;L-ALPHA-PHOSPHATIDYLETHANOLAMINE, DIOLEOYL;L-ALPHA-PHOSPHATIDYLETHANOLAMINE, DIOLEOYL (C18:1,[CIS]-9);L-BETA,GAMMA-DIOLEOYL-ALPHA-CEPHALIN;DIOLEOYL PHOSPHATIDYL ETHANOLAMINE |
| CAS号 | 4004-05-1 |
| 分子式 | C41H78NO8P |
| 分子量 | 744.05 |
| EINECS号 | 200-663-8 |
| 相关类别 | 酯;合成磷脂;药用辅料;DOPE磷脂产品;磷脂-DOPE;新冠疫苗辅料 |
| Mol文件 | 4004-05-1.mol |
| 结构式 |  |
1,2-二油酰-SN-甘油-3-磷酰乙醇胺 性质
| 熔点 | 200°C(lit.) |
|---|---|
| 沸点 | 759.2±70.0 °C(Predicted) |
| 密度 | 1.008±0.06 g/cm3(Predicted) |
| 储存条件 | -20°C |
| 溶解度 | 二甲基亚砜：31.25 mg/mL（42.00 mM） |
| 形态 | 冻干粉 |
| 酸度系数(pKa) | 1.17±0.50(Predicted) |
| 颜色 | 白色至浅黄色至浅橙色 |
| BRN | 1718431 |
| InChIKey | MWRBNPKJOOWZPW-XFBMKQTANA-N |
| SMILES | [C@H](COP(O)(=O)OCCN)(COC(=O)CCCCCCC/C=C\CCCCCCCC)OC(=O)CCCCCCC/C=C\CCCCCCCC |&1:0,r| |
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) 是阳离子脂质体的中性辅助脂质 (helper lipid)，与阳离子磷脂结合，提高裸 siRNA 的转染效率。
IC50: helper lipid for liposome
In this study, each siRNA is encapsulated in LNP (cationic lipid-A: PEG2000-DMPE: DOPE = 47.8: 5.18: 47.1 molar percent).With the neutral lipid for the LNP is DOPE , LNP exerts knock-down (KD) effecton macrophages and DCs and Liposome-containing DOPE shows fusogenicity.LNP/siRNA significantly suppresses CD45 protein expression at an inhibition rate of 30% on macrophages and DCs but not on monocytes, neutrophils, plasmacytoid DCs, or B cells.LNP has the potential to be an efficient siRNA delivery system not only for murine but also for human macrophages and DCs.
安全信息
| 危险品标志 | Xn |
|---|---|
| 危险类别码 | 22-38-40-48/20/22-67-36/38-20-63 |
| 安全说明 | 36/37-26 |
| 危险品运输编号 | UN 1888 6.1/PG 3 |
| WGK Germany | 3 |
| F | 8-10-23 |
| 海关编码 | 29232000 |
| 提供商 | 语言 |
|---|---|
|
英文
|