| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:VH032-PEG5-C6-Cl
CAS:1799506-06-1
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
Bide Pharmatech Ltd.
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| Tel: |
400-1647117 13681763483 |
| Email: |
product02@bidepharm.com |
| Products Intro: |
Product Name:(2S,4R)-N-((S)-2-(tert-Butyl)-24-chloro-4-oxo-6,9,12,15,18-pentaoxa-3-azatetracosanoyl)-4-hydroxy-1-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
CAS:1799506-06-1
Purity:98% Package:10mg;25mg;50mg;100mg;250mg Remarks:BD00820369
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| | HaloPROTAC 2 Basic information |
| Product Name: | HaloPROTAC 2 | | Synonyms: | HaloPROTAC 2;L-Prolinamide, N-(21-chloro-1-oxo-3,6,9,12,15-pentaoxaheneicos-1-yl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(2S,4R)-N-((S)-2-(tert-Butyl)-24-chloro-4-oxo-6,9,12,15,18-pentaoxa-3-azatetracosanoyl)-4-hydroxy-1-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2S,4R)-1-[(2S)-2-(21-chloro-3,6,9,12,15-pentaoxahenicosanamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide | | CAS: | 1799506-06-1 | | MF: | C38H59ClN4O9S | | MW: | 783.41 | | EINECS: | | | Product Categories: | | | Mol File: | 1799506-06-1.mol |  |
| | HaloPROTAC 2 Chemical Properties |
| Boiling point | 940.5±65.0 °C(Predicted) | | density | 1.200±0.06 g/cm3(Predicted) | | storage temp. | -80°C, protect from light, stored under nitrogen | | solubility | DMSO : ≥ 50 mg/mL (63.82 mM) | | pka | 13.54±0.46(Predicted) | | form | Viscous Liquid |
| | HaloPROTAC 2 Usage And Synthesis |
| Description | HaloPROTAC2 is a novel HaloPROTAC degrader, inducing degradation of HaloTag fusion proteins. | | Uses | VH032-PEG5-C6-Cl (HaloPROTAC 2) is a conjugate of ligands for E3 and 21-atom-length linker. The connector of linker is Halogen group. VH032-PEG5-C6-Cl incorporates the VH032 based VHL ligand and 5-unit PEG linker. VH032-PEG5-C6-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1]. | | IC 50 | VHL | | References | [1] Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins. ACS Chem Biol. 2015 Aug 21;10(8):1831-7. DOI:10.1021/acschembio.5b00442 |
| | HaloPROTAC 2 Preparation Products And Raw materials |
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