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| | HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS Basic information |
| Product Name: | HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS | | Synonyms: | 17(20),24-trien-21-oicacid,6,16-bis(acetyloxy)-3,7-dioxo-29-nordammara-(4;6-beta,8-alpha,9-beta,13-alpha,14-beta,16-beta,17-beta)--alph;fumigacin;HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS;(4α,8α,9β,13α,14β,17Z)-6β,16β-Bis(acetyloxy)-3,7-dioxo-29-nordammara-1,17(20),24-trien-21-oic acid;(8α,9β,13α,14β,17Z)-6β,16β-Bis(acetyloxy)-3,7-dioxo-29-nordammara-1,17(20),24-trien-21-oic acid;(8α,9β,13α,14β,17Z)-6β,16β-Diacetoxy-3,7-dioxo-29-nor-5α-dammara-1,17(20),24-trien-21-oic acid;29-Nordammara-1,17(20),24-trien-21-oic acid, 6,16-bis(acetyloxy)-3,7-dioxo-, (4α,6β,8α,9β,13α,14β,16β,17Z)- | | CAS: | 29400-42-8 | | MF: | C33H44O8 | | MW: | 568.7 | | EINECS: | | | Product Categories: | | | Mol File: | 29400-42-8.mol |  |
| | HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS Chemical Properties |
| Melting point | 215° | | alpha | D25 -121° (chloroform) | | Boiling point | 552.56°C (rough estimate) | | density | 1.1062 (rough estimate) | | refractive index | 1.4900 (estimate) | | storage temp. | 2-8°C | | solubility | DMF:30.0(Max Conc. mg/mL);52.75(Max Conc. mM)
DMSO:20.0(Max Conc. mg/mL);35.17(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);35.17(Max Conc. mM) | | form | A crystalline solid | | pka | 4.05±0.41(Predicted) |
| RTECS | RC1370000 | | HS Code | 29419000 |
| | HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS Usage And Synthesis |
| Description | Helvolic acid is a mycotoxin originally isolated from A. fumigatus that has broad-spectrum antibiotic activity against Gram-positive and Gram-negative bacteria. At 4-16 mg/L, it acted synergistically with erythromycin (500-2,000 mg/L) in vitro on five multi-drug resistant strains of S. aureus. At 10 mg/kg/d, it reduced tumor growth and prolonged survival synergistically with cyclophosphamide (20 mg/kg/d) in a mouse model of sarcoma but had no effect when administered alone. | | Uses | Helvolic acid is a mycotoxin with antibacterial activity. | | Definition | ChEBI: A steroid C-21 acid having a 29-nordammarane skeleton substituted with an acetoxy group at C-16 and oxo groups at C-3 and -7, with double bonds at C-1, -17(20) and -24. |
| | HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS Preparation Products And Raw materials |
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