| Company Name: |
Asperillum Ltm Gold |
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15920419256 |
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huangxishan13@foxmail.com |
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Lynnchem |
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HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS manufacturers
- Helvolic acid
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- $578.00
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2026-07-15
- CAS:29400-42-8
- Purity:
- Supply Ability: 10g
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| | HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS Basic information |
| Product Name: | HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS | | Synonyms: | 17(20),24-trien-21-oicacid,6,16-bis(acetyloxy)-3,7-dioxo-29-nordammara-(4;6-beta,8-alpha,9-beta,13-alpha,14-beta,16-beta,17-beta)--alph;fumigacin;HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS;(4α,8α,9β,13α,14β,17Z)-6β,16β-Bis(acetyloxy)-3,7-dioxo-29-nordammara-1,17(20),24-trien-21-oic acid;(8α,9β,13α,14β,17Z)-6β,16β-Bis(acetyloxy)-3,7-dioxo-29-nordammara-1,17(20),24-trien-21-oic acid;(8α,9β,13α,14β,17Z)-6β,16β-Diacetoxy-3,7-dioxo-29-nor-5α-dammara-1,17(20),24-trien-21-oic acid;29-Nordammara-1,17(20),24-trien-21-oic acid, 6,16-bis(acetyloxy)-3,7-dioxo-, (4α,6β,8α,9β,13α,14β,16β,17Z)- | | CAS: | 29400-42-8 | | MF: | C33H44O8 | | MW: | 568.7 | | EINECS: | | | Product Categories: | | | Mol File: | 29400-42-8.mol |  |
| | HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS Chemical Properties |
| Melting point | 215° | | alpha | D25 -121° (chloroform) | | Boiling point | 552.56°C (rough estimate) | | density | 1.1062 (rough estimate) | | refractive index | 1.4900 (estimate) | | storage temp. | 2-8°C | | solubility | DMF:30.0(Max Conc. mg/mL);52.75(Max Conc. mM)
DMSO:20.0(Max Conc. mg/mL);35.17(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);35.17(Max Conc. mM) | | form | A crystalline solid | | pka | 4.05±0.41(Predicted) | | color | White to off-white |
| RTECS | RC1370000 | | HS Code | 29419000 |
| | HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS Usage And Synthesis |
| Description | Helvolic acid is a mycotoxin originally isolated from A. fumigatus that has broad-spectrum antibiotic activity against Gram-positive and Gram-negative bacteria. At 4-16 mg/L, it acted synergistically with erythromycin (500-2,000 mg/L) in vitro on five multi-drug resistant strains of S. aureus. At 10 mg/kg/d, it reduced tumor growth and prolonged survival synergistically with cyclophosphamide (20 mg/kg/d) in a mouse model of sarcoma but had no effect when administered alone. | | Uses | Helvolic acid is a mycotoxin with antibacterial activity. | | Definition | ChEBI: A steroid C-21 acid having a 29-nordammarane skeleton substituted with an acetoxy group at C-16 and oxo groups at C-3 and -7, with double bonds at C-1, -17(20) and -24. | | References | [1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] PAMODA B RATNAWEERA. Helvolic acid, an antibacterial nortriterpenoid from a fungal endophyte, Xylaria sp. of orchid Anoectochilus setaceus endemic to Sri Lanka.[J]. Mycology, 2014, 5 1: 23-28. DOI: 10.1080/21501203.2014.892905
[3] LING QIN. In vitro synergistic antibacterial activities of helvolic acid on multi-drug resistant Staphylococcus aureus.[J]. Natural Product Research, 2009, 23 4: 309-318. DOI: 10.1080/14786410801972813
[4] JIAN-HUI XIAO. Synergistic antitumor efficacy of antibacterial helvolic acid from Cordyceps taii and cyclophosphamide in a tumor mouse model.[J]. Experimental Biology and Medicine, 2017, 242 2: 214-222. DOI: 10.1177/1535370216668051 |
| | HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS Preparation Products And Raw materials |
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