| Company Name: |
Suzhou Zhixin Biotechnology Co., Ltd.
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| Tel: |
0512-65118909 18100677375 |
| Email: |
sales@szzxbio.com |
| Products Intro: |
Product Name:ZG-10
CAS:1408077-04-2
Purity:98%+ Package:1g;10g;100g
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:ZG-10
CAS:1408077-04-2
Purity:99.91% Package:1mg/RMB 1300;5mg/RMB 3250;10mg/RMB 4750
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| Product Name: | ZG-10 | | Synonyms: | ZG-10;Benzamide, 4-[[4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]-N-[3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]- | | CAS: | 1408077-04-2 | | MF: | C28H27N7O2 | | MW: | 493.56 | | EINECS: | | | Product Categories: | | | Mol File: | 1408077-04-2.mol |  |
| | ZG-10 Chemical Properties |
| | ZG-10 Usage And Synthesis |
| Description | ZG-10 is a JNK1 inhibitor, which targets JNK and p38 signaling. | | Uses | ZG-10 (JNK-IN-2) is a JNK inhibitor, with IC50 values of 809 nM, 1140 nM and 709 nM for JNK1, JNK2, and JNK3, respectively. ZG-10 (JNK-IN-2) is a potential anti-SARS-CoV-2 agent[1][2]. | | Definition | ChEBI: 4-[[4-(dimethylamino)-1-oxobut-2-enyl]amino]-N-[3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide is a member of benzamides. | | IC 50 | JNK1: 809 nM (IC50); JNK2: 1140 nM (IC50); JNK3: 709 nM (IC50) | | References | [1] Tinghu Zhang, et al. Discovery of potent and selective covalent inhibitors of JNK. Chem Biol. 2012 Jan 27;19(1):140-54. DOI:10.1016/j.chembiol.2011.11.010
[2] Rui Zhang, et al. Inflammatory activation and immune cell infiltration are main biological characteristics of SARS-CoV-2 infected myocardium. Bioengineered. 2022 Feb;13(2):2486-2497. DOI:10.1080/21655979.2021.2014621 |
| | ZG-10 Preparation Products And Raw materials |
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