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| | Mycophenolate mofetil 製品概要 |
| 化学名: | | | 英語化学名: | Mycophenolate mofetil | | 别名: | Mycophenolate mofetil###115007-34-6;MYCOPHENOLATE MOFETIL,98.0%~102%,ENTERPRISE STANDARD;AKOS 92025;4-HEXENOIC ACID,6-(1,3-DIHYDRO-4-HYDROXY-6-METHOXY-7-METHYL-3-OXO-5-ISOBENZOFURANYL)-4-METHYL-,2-(4-MORPHOLINYL)ETHYL ESTER;2-Morpholin-4-ylethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-isobenzofuran-5-yl)-4-methyl-hex-4-enoate;Mycophenolate mofetil;Mycophenolate Mofetil（MMF）;Matimaikaofenzhi | | CAS番号: | 115007-34-6 | | 分子式: | C23H31NO7 | | 分子量: | 433.49 | | EINECS: | 680-628-5 | | カテゴリ情報: | Anti-cancer & immunity;API;115007-34-6 | | Mol File: | 115007-34-6.mol |  |
| | Mycophenolate mofetil 物理性質 |
| 溶解性 | Practically insoluble in water, freely soluble in acetone, sparingly soluble in anhydrous ethanol. | | BCS Class | 2 | | InChI | InChI=1S/C23H31NO7/c1-15(5-7-19(25)30-13-10-24-8-11-29-12-9-24)4-6-17-21(26)20-18(14-31-23(20)27)16(2)22(17)28-3/h4,26H,5-14H2,1-3H3/b15-4+ | | InChIKey | RTGDFNSFWBGLEC-SYZQJQIISA-N | | SMILES | C12COC(=O)C=1C(O)=C(C/C=C(\C)/CCC(=O)OCCN1CCOCC1)C(OC)=C2C | | CAS データベース | 115007-34-6(CAS DataBase Reference) |
| | Mycophenolate mofetil Usage And Synthesis |
| 化学的特性 | White or almost white, crystalline powder. | | 使用 | Inhibitor of nucleic acid synthesis; immunomodulator. | | 使用 | Mycophenolate Mofetil is an intermediate in the synthesis of (4Z)-Mycophenolate Mofetil (M831455), a degradation product of Mycophenolate mofetil, an immunosuppressant. | | 定義 | ChEBI: Mycophenolate mofetil is a carboxylic ester resulting from the formal condensation between the carboxylic acid group of mycophenolic acid and the hydroxy group of 2-(morpholin-4-yl)ethanol. In the liver, it is metabolised to mycophenolic acid, an immunosuppressant for which it is a prodrug. It is widely used to prevent tissue rejection following organ transplants as well as for the treatment of certain autoimmune diseases. It has a role as an immunosuppressive agent, a prodrug, an EC 1.1.1.205 (IMP dehydrogenase) inhibitor and an anticoronaviral agent. It is a gamma-lactone, a member of phenols, an ether, a carboxylic ester and a tertiary amino compound. It is functionally related to a mycophenolic acid and a 2-(morpholin-4-yl)ethanol. | | 適応症 | Mycophenolate mofetil (CellCept), in conjunction with
cyclosporine and corticosteroids, has clinical applications
in the prevention of organ rejection in patients receiving
allogeneic renal and cardiac transplants. By effectively
inhibiting de novo purine synthesis, it can
impair the proliferation of both T and B lymphocytes.
Following oral administration, mycophenolate mofetil
is almost completely absorbed from the GI tract, metabolized
in the liver first to the active compound mycophenolic
acid, and then further metabolized to an inactive
glucuronide.
Early clinical trials indicate that mycophenolate
mofetil in conjunction with cyclosporine and corticosteroids
is a more effective regimen than azathioprine
in preventing the acute rejection of transplanted organs.
GI side effects are most common. | | brand name | Cellcept (Roche). | | 副作用 | The main side effects include an
increased incidence of herpes zoster, neutropenia, gastrointestinal symptoms,
and opportunistic infections. In the transplant literature, 1% to 2%
of patients will develop a lymphoproliferative malignancy at the doses
recommended for psoriasis. This is a teratogen and should be avoided in
women of childbearing age. |
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