6,7-Dimethoxy-3',4',5-trihydroxyflavone

6,7-Dimethoxy-3',4',5-trihydroxyflavone Suppliers list

Company Name:	Chengdu Biopurify Phytochemicals Ltd.
Tel:	+86-028-82633397 18982077548
Email:	cwb1@biopurify.cn

Company Name:	Shanghai Tauto Biotech Co., Ltd.
Tel:	021-51320588
Email:	tauto@tautobiotech.com

Company Name:	Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel:	0510-85629785 18013409632;
Email:	sales@reading-chemicals.com

6,7-Dimethoxy-3',4',5-trihydroxyflavone manufacturers

6,7-Dimethoxy-3',4',5-trihydroxyflavone Basic information

Product Name:	6,7-Dimethoxy-3',4',5-trihydroxyflavone
Synonyms:	6,7-DIMETHOXY-3,4'',5-TRIHYDROXYFLAVONE 95+%;3'-Hydroxy-6-methoxygenkwanin;6-Hydroxyluteolin-6,7-dimethyl ether;6-Methoxyluteolin 7-methyl ether;Crisiliol;6,7-DIMETHOXY-5,3',4'-TRIHYDROXYFLAVONE;3',4',5-Trihydroxy-6,7-dimethoxy;Cirsiliol >=95% (HPLC)
CAS:	34334-69-5
MF:	C17H14O7
MW:	330.29
EINECS:
Product Categories:	Flavones
Mol File:	34334-69-5.mol

6,7-Dimethoxy-3',4',5-trihydroxyflavone Chemical Properties

Melting point	280-281.5℃ (methanol )
Boiling point	616.1±55.0 °C(Predicted)
density	1.483±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Acetone: soluble; Chloroform: soluble; DMSO: soluble
form	powder
pka	6.31±0.40(Predicted)
color	white to beige
InChI	1S/C17H14O7/c1-22-14-7-13-15(16(21)17(14)23-2)11(20)6-12(24-13)8-3-4-9(18)10(19)5-8/h3-7,18-19,21H,1-2H3
InChIKey	IMEYGBIXGJLUIS-UHFFFAOYSA-N
SMILES	[o]1c2c([c](cc1c3cc(c(cc3)O)O)=O)c(c(c(c2)OC)OC)O

Safety Information

MSDS Information

6,7-Dimethoxy-3',4',5-trihydroxyflavone Usage And Synthesis

Uses	Cirsiliol is a potent and selective 5-lipoxygenase inhibitor and a competitive low affinity benzodiazepine receptor ligand.
Definition	ChEBI: A dimethoxyflavone that is flavone substituted by methoxy groups at positions 6 and 7 and hydroxy groups at positions 5, 3' and 4' respectively.
Biological Activity	Cirsiliol is a flavonoid th at displays anti-inflammatory, anti-oxidant, anti-proliferative, and anti-bacterial activities. Cirsiliol sensitizes non-small cell lung cancer cell lines (NSCLC) to radiation therapy. Cirsiliol inhibits epithelial-mesenchymal transition likely by induction of tumor-suppressive miR-34a, which suppresses Notch-1 expression NSCLC.
in vivo	In xenograft mouse model, tumor volume is significantly reduced by combinational treatment with irradiation and rhamnetin or cirsiliol compared with irradiation alone^[2].
IC 50	5-Lipoxygenase
References	[1] Mustafa EH, et al. Effects of cirsiliol, a flavone isolated from Achillea fragrantissima, on rat isolated ileum. Gen Pharmacol. 1992 May;23(3):555-60. DOI:10.1016/0306-3623(92)90127-6 [2] Kang J, et al. Rhamnetin and cirsiliol induce radiosensitization and inhibition of epithelial-mesenchymal transition (EMT) by miR-34a-mediated suppression of Notch-1 expression in non-small cell lung cancer cell lines. J Biol Chem. 2013 Sep 20;288(38):27343-57. DOI:10.1074/jbc.M113.490482

6,7-Dimethoxy-3',4',5-trihydroxyflavone Preparation Products And Raw materials

Raw materials	4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-5,6,7-trimethoxy--->3,6-Dihydroxy-2,4-dimethoxyacetophenone-->3,4-Bis(benzyloxy)benzoyl chloride-->2,3,4-Trimethoxy-6-hydroxyacetophenone
Preparation Products	cirsilineol

Tag:6,7-Dimethoxy-3',4',5-trihydroxyflavone(34334-69-5) Related Product Information

Nobiletin 3’,4’,5’-Trihydroxy-6,7-dimethoxyflavone ARTEMETIN CASTICIN Jaceosidin Tricin cirsilineol 3',4',5',6,7,8-Hexamethoxy-5-hydroxyflavone 3'-Benzyloxy-4',5,6,7-tetramethoxyflavone 3',5-Dihydroxy-4',6,7-trimethoxyflavone 3',4',5',5,6,7-Hexamethoxyflavone 3,4'-Dimethoxy-3',5,7-trihydroxyflavone 5-Demethylnobiletin 3,5-Dimethoxy-7,3',4'-trihydroxyflavone Eupatorin-5-methyl ether 6,7-Dimethoxy-3',4',5-trihydroxyflavone nepitrin 5,3',4'-trihydroxy-3,6,7,8-tetramethoxyflavone