黄花夹竹桃黄酮
| 中文名称 | 黄花夹竹桃黄酮 |
|---|---|
| 中文同义词 | 黄花夹竹桃黄酮;化合物 T13922 |
| 英文名称 | Thevetiaflavone |
| 英文同义词 | 5-O-METHYLAPIGENIN;4',7-Dihydroxy-5-methoxyflavone;Apigenin 5-methylether;7-Hydroxy-2-(4-hydroxyphenyl)-5-methoxy-4H-chromen-4-one;4H-1-Benzopyran-4-one,7-hydroxy-2-(4-hydroxyphenyl)-5-methoxy-;Apigenin 5-O-monomethyl ether;Apigenin-5-methyl ether,5-0-Methylapigenin;Flavone,4',7-dihydroxy-5-methoxy- (8CI) |
| CAS号 | 29376-68-9 |
| 分子式 | C16H12O5 |
| 分子量 | 284.26 |
| EINECS号 | |
| 相关类别 | 黄酮;Miscellaneous Natural Products |
| Mol文件 | Mol File |
| 结构式 |  |
黄花夹竹桃黄酮 性质
| 熔点 | 263℃ |
|---|---|
| 沸点 | 567.9±50.0 °C(Predicted) |
| 密度 | 1.420 |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 6.67±0.40(Predicted) |
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Bcl-2
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Bax
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Caspase-3
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Thevetiaflavone, a natural flavonoid obtained from Wikstroemia indica, could improve cell viability and suppresses the leakage of lactate dehydrogenase from the cytoplasm. Further investigation of the mechanisms demonstrated that Thevetiaflavone decreases overproduction of ROS and ameliorates ROS‑mediated mitochondrial dysfunction, including collapse of mitochondrial membrane potential and mitochondrial permeability transition pore opening. Thevetiaflavone reduces the intracellular Ca 2+ level, which is closely associated with mitochondrial function and interplays with ROS. Furthermore, Thevetiaflavone inhibits apoptosis in PC12 cells through upregulating the expression of Bcl‑2 and downregulating that of Bax and caspase‑3 in addition to increasing the activity of caspase‑3. These results further indicate the protective effects of thevetiaflavone in vivo and its application in the clinic.