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| 化学名: | デソニド | | 英語化学名: | Desonide | | 别名: | DESONIDE;1,4-PREGNADIEN-11-BETA, 16-ALPHA, 17,21-TETROL-3,20-DIONE 16,17-ACETONIDE;(11b,16a)-11,21-dihydroxy-16,17-((1-methylethylidene)bis(oxy))-pregna-1,4-diene-3,20-dione;16-alpha-hydroxyprednisole-16,17-acetonide;17-acetonide,16-alpha-hydroxy-prednisolone-1;d-2083;steroderm;Desonidemicro | | CAS番号: | 638-94-8 | | 分子式: | C24H32O6 | | 分子量: | 416.51 | | EINECS: | 211-351-6 | | カテゴリ情報: | SPORANOX;Hormone Drugs;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;API | | Mol File: | 638-94-8.mol |  |
| 融点 | 272-274?C | | 沸点 | 580.1±50.0 °C(Predicted) | | 比重(密度) | 1.30±0.1 g/cm3(Predicted) | | 貯蔵温度 | Sealed in dry,2-8°C | | 溶解性 | DMF (Slightly, Sonicated), DMSO (Sparingly), Methanol (Slightly, Heated) | | 外見 | Solid | | 酸解離定数(Pka) | 12.87±0.10(Predicted) | | 色 | White to Off-White | | CAS データベース | 638-94-8(CAS DataBase Reference) |
| HSコード | 2937290000 | | 毒性 | LD50 in rats (mg/kg): 93 s.c. (Phillips) |
| 外観 | 白色～ほとんど白色粉末～結晶 | | 効能 | 抗炎症薬, グルココルチコイド受容体作動薬 | | 化学的特性 | Off-White Solid | | Originator | Tridesilon,Dome,US,1972 | | 使用 | Anti-inflammatory. Desonide has also been found as an impurity in budesonide (B689490). | | 使用 | antifungal | | 使用 | Desonide(Budesonide EP Impurity F) is an impurity of Budesonide (B689490), an anti-inflammatory. | | 適応症 | Desonide (DesOwen, Tridesilon) is a synthetic corticosteroid. | | 定義 | ChEBI: Triamcinolone acetonide with hydrogen instead of the fluorine substituent at position 9. A corticosteroid anti-inflammatory, it is used topically as a cream, ointment or lotion for the treatment of various skin disorders. | | Manufacturing Process | Preparation of 11β,21-Dihydroxy-16α,17α-Isopropylidenedioxy-1,4-
Pregnadiene-3,20-Dione: A solution of 11β,16α,17α,21-tetrahydroxy-1,4-
pregnadiene-3,20-dione (40 mg) in acetone (10 ml) containing hydrochloric
acid (three drops; d 1.19) is boiled 3n the steam bath for two minutes and then allowed to stand for eighteen hours at room temperature. The reaction
mixture is diluted with water (50 ml) and extracted with chloroform (3x25
ml), the combined extracts then being washed with water (30 ml) and dried
over anhydrous sodium sulfate. The residue obtained by removal of solvent
crystallized from ethyl acetate-petroleum ether as small plates (25 mg),
melting point 257°-260°C. | | brand name | Desowen (Galderma); Tridesilon (Perrigo). | | Therapeutic Function | Antiinflammatory |
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