L-Prolinamide, N-[(1-fluorocyclopropyl)carbonyl]-3-mercapto-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-

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L-Prolinamide, N-[(1-fluorocyclopropyl)carbonyl]-3-mercapto-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Suppliers list
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L-Prolinamide, N-[(1-fluorocyclopropyl)carbonyl]-3-mercapto-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Basic information
Product Name:L-Prolinamide, N-[(1-fluorocyclopropyl)carbonyl]-3-mercapto-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
Synonyms:(2S,4R)-1-((R)-2-(1-Fluorocyclopropanecarboxamido)-3-mercapto-3-methylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;VH 101, thiol;(2S,4R)-1-((R)-2-(1-Fluorocyclopropane-1-carboxamido)-3-mercapto-3-methylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;L-Prolinamide, N-[(1-fluorocyclopropyl)carbonyl]-3-mercapto-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
CAS:2358775-81-0
MF:C25H31FN4O4S2
MW:534.67
EINECS:
Product Categories:
Mol File:2358775-81-0.mol
L-Prolinamide, N-[(1-fluorocyclopropyl)carbonyl]-3-mercapto-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Structure
L-Prolinamide, N-[(1-fluorocyclopropyl)carbonyl]-3-mercapto-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Chemical Properties
Boiling point 823.6±65.0 °C(Predicted)
density 1.38±0.1 g/cm3(Predicted)
pka10.20±0.10(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
L-Prolinamide, N-[(1-fluorocyclopropyl)carbonyl]-3-mercapto-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Usage And Synthesis
UsesVH 101, thiol (compound 20) is a VHL ligand for the synthesis of PROTACs[1].
IC 50VHL
storageStore at -20°C
References[1] Miriam Girardini, et al. Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs. Bioorg Med Chem. 2019 Jun 15;27(12):2466-2479. DOI:10.1016/j.bmc.2019.02.048
L-Prolinamide, N-[(1-fluorocyclopropyl)carbonyl]-3-mercapto-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Preparation Products And Raw materials
Tag:L-Prolinamide, N-[(1-fluorocyclopropyl)carbonyl]-3-mercapto-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-(2358775-81-0) Related Product Information
VH032 thiol VH 101, phenol VH-032 L-Prolinamide, N-[(1-fluorocyclopropyl)carbonyl]-3-methyl-L-valyl-N-[[2-[(6-aminohexyl)oxy]-4-(4-methyl-5-thiazolyl)phenyl]methyl]-4-hydroxy-, hydrochloride (1:2), (4R)- VH 032 amide-alkylC2-acid (2S,4R)-1-((S)-2-(1-Fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-N-(2-(2-(4-formylphenoxy)ethoxy)-4-(4-methylthiazol-5-yl)benzyl)-4-hydroxypyrrolidine-2-carboxamide