转铁蛋白受体结合肽
| 中文名称 | 转铁蛋白受体结合肽 |
|---|---|
| 中文同义词 | 转铁蛋白受体结合肽 |
| 英文名称 | L-Proline, L-threonyl-L-histidyl-L-arginyl-L-prolyl-L-prolyl-L-methionyl-L-tryptophyl-L-seryl-L-prolyl-L-valyl-L-tryptophyl- |
| 英文同义词 | L-Proline, L-threonyl-L-histidyl-L-arginyl-L-prolyl-L-prolyl-L-methionyl-L-tryptophyl-L-seryl-L-prolyl-L-valyl-L-tryptophyl-;TfR-T12 |
| CAS号 | 344618-30-0 |
| 分子式 | C71H99N19O15S |
| 分子量 | 1490.73 |
| EINECS号 | |
| 相关类别 | 定制多肽 |
| Mol文件 | 344618-30-0.mol |
| 结构式 |  |
转铁蛋白受体结合肽 性质
| 密度 | 1.53±0.1 g/cm3(Predicted) |
|---|---|
| 酸度系数(pKa) | 3.42±0.20(Predicted) |
TfR-T12 是一个能透过血脑屏障的转铁蛋白受体 (TfR) 的结合肽，显示出 nM 水平的结合活性。
TfR-T12 binds to the TfR and is subsequently internalized into TfR-expressing cells.
TfR-T12 is a synthetic peptide obtained by phage display, and is able to bind a different site on TfRs compared with transferrin. TfR-T12 can be chemically conjugated with a pegylated lipid derivative, 3-(N-succinimidyloxyglutaryl)aminopropyl- polyethyleneglycol(2000)- carbamyl distearoyl phosphatidylethanolamine (NHS-PEG2000-DSPE), and used as a functional material to construct the multifunctional lipid vesicles.