光克洛
中文名称 | 光克洛 |
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中文同义词 | 光克洛;光克洛(HPPH) |
英文名称 | 14-Ethyl-9-(1-(hexyloxy)ethyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbine propanoic acid |
英文同义词 | Photochlor (HPPH);3-Phorbinepropanoic acid, 14-ethyl-9-[1-(hexyloxy)ethyl]-4,8,13,18 -tetramethyl-20-oxo-, (3S,4S)-;Sulcardine;14-Ethyl-9-(1-(hexyloxy)ethyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbine propanoic acid;2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a;(3S,4S)-14-Ethyl-9-[1-(hexyloxy)ethyl]-4,8,13,18-tetramethyl-20-oxo-3-phorbinepropanoic acid;3-Devinyl-3-(1'-hexyloxy)ethylpyropheophorbide A;Photochlor (HTTP) |
CAS号 | 149402-51-7 |
分子式 | C39H48N4O4 |
分子量 | 636.82 |
EINECS号 | |
相关类别 | 原料药【仅供科研】;科研原药系列;合成材料中间体 |
Mol文件 | 149402-51-7.mol |
结构式 |
光克洛 性质
沸点 | 992.5±65.0 °C(Predicted) |
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密度 | 1.184 |
储存条件 | Sealed in dry,Room Temperature |
溶解度 | DMSO:3.0(最大浓度 mg/mL);4.7(最大浓度 mM) |
形态 | 结晶固体 |
Fluorescence image of 4T1 cells incubated with 0.49 µg/mL GO-PEG, 1 μM HPPH (free HPPH) or equivalent amount of GO-PEG-HPPH (1 µM HPPH and 0.49 µg/mL GO-PEG) after 24 h. The cellular uptake of GO-PEG-HPPH and HPPH is investigated with 4T1 murine mammary cancer cells. The cells are incubated with GO-PEG-HPPH and free HPPH at equivalent HPPH concentration (1 µM) for 24 h and then observed with a confocal microscope. Cells treated with GO-PEG-HHPH shows stronger fluorescence signal than those treated with free HPPH. In fact, the fluorescence of HPPH is rather weak.
Tumors are treated with an immune-enhancing PDT regimen followed by a tumor-controlling PDT regimen can leads to enhancement of anti-tumor immunity, while retaining effective control of primary tumor growth. To test this hypothesis, a combination treatment regimen is devised in which Colo26-HA tumor-bearing BALB/c mice are treated with a HPPH-PDT regimen known to lead to enhanced anti-tumor immunity (0.4 μmoles/kg HPPH followed 18 h later by illumination with 665 nm light for a total dose of 48 J/cm 2 ). Following illumination, mice are rested for 9 days; on the ninth day, mice are injected with HPPH. On day 10 following the first treatment, tumors are treated with a tumor control treatment regimen (illumination with 665 nm light for a total dose of 132 J/cm 2 given).