MKT 077
中文名称 | MKT 077 |
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中文同义词 | 1-乙基-2-((Z)-((Z)-3-乙基-5-(3-甲基苯并[D]噻唑-2(3H)-亚基)-4-氧代噻唑烷-2-亚基)甲基)吡啶-1-鎓氯化物;化合物MKT-077;MKT 077,结合MOT-2 |
英文名称 | MKT 077 |
英文同义词 | MKT 077;FJ 776;1-Ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-pyridinium chloride;MKT-077, ≥98% (HPLC);1-Ethyl-2-((Z)-((Z)-3-ethyl-5-(3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)methyl)pyridin-1-ium chloride;MKT-077 >=98% (HPLC), powder;Pyridinium, 1-ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-, chloride (1:1);MKT077;MKT-077;FJ-776 |
CAS号 | 147366-41-4 |
分子式 | C21H22ClN3OS2 |
分子量 | 432.00188 |
EINECS号 | |
相关类别 | |
Mol文件 | 147366-41-4.mol |
结构式 |
MKT 077 性质
储存条件 | 2-8°C |
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溶解度 | 在水中的溶解度为10mg/mL,澄清 |
形态 | 粉末 |
颜色 | 橙色至红色 |
HSP70
|
MKT-077 is a rhodacyanine dye and also a heat shock protein 70 (Hsp70) inhibitor which exhibits significant antitumor activity. MKT-077 treatment (0.1 to 10 µM dose ranges) for 48 hours can effectively decrease TT cell viability. MKT-077 treatment results in accumulation of cells in the G0/G1 phase in a dose-dependent manner, and also increases sub-G0/G1 phase population in TT cell culture in a dose-dependent manner. MKT-077 also downregulates cellular levels of the proliferation marker, Ki67, and the S-phase transcription factor, E2F-1, in TT and MZ-CRC-1 cells. Moreover, flow cytometry using different doses of MKT-077 reveales that TT cells can uptake and retain MKT-077 at significantly higher levels than MZ-CRC-1 cells. MKT-077 has EC 50 values of 1.4±0.2 and 2.2±0.2 μM against MDA-MB-231 and MCF7 breast cancer cells, respectivelyl.
Systemic administration of MKT-077 significantly delays the growth of TT xenografts in mice throughout the treatment. At the end of MKT-077 treatment, it is found that tumor weights are about two-times less in MKT-077-treated group than in control group. MKT-077 treatment also results in weight loss and general toxicity in animals. Results show that the succinate-induced, ADP-stimulated respiratory rate in mitochondria isolated from the liver of rats treated with a bolus i.v. injection of 15 mg MKT-077 1kg body weight each day for 5 days is significantly lower than that of untreated controls.
安全信息
WGK Germany | 3 |
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RTECS号 | UU4023332 |
毒性 | LD50 intraperitoneal in mouse: 50mg/kg |
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-15096 | MKT-077 | 1 mg | 419元 | |
2024/08/19 | HY-15096 | MKT 077 MKT-077 | 147366-41-4 | 5mg | 1000元 |