MKT 077
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- CAS号:
- 147366-41-4
- 英文名:
- MKT 077
- 英文别名:
- FJ 776;MKT 077;MKT-077, ≥98% (HPLC);MKT077;MKT-077;FJ-776;MKT-077 >=98% (HPLC), powder;MKT-077,Heat shock proteins,FJ 776,HSP,Inhibitor,inhibit,FJ776;1-Ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-pyridinium chloride;Pyridinium, 1-ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-, chloride (1:1);1-Ethyl-2-((Z)-((Z)-3-ethyl-5-(3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)methyl)pyridin-1-ium chloride
- 中文名:
- MKT 077
- 中文别名:
- 化合物MKT-077;MKT 077,结合MOT-2;1-乙基-2-((Z)-((Z)-3-乙基-5-(3-甲基苯并[D]噻唑-2(3H)-亚基)-4-氧代噻唑烷-2-亚基)甲基)吡啶-1-鎓氯化物
- CBNumber:
- CB31356358
- 分子式:
- C21H22ClN3OS2
- 分子量:
- 432.00188
- MOL File:
- 147366-41-4.mol
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MKT 077化学性质
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储存条件:
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2-8°C
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溶解度:
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H2O: soluble10mg/mL, clear
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形态:
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powder
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颜色:
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orange to red
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MKT 077性质、用途与生产工艺
MKT-077 (FJ-776)是一种新合成的、具有高水溶性的复合份菁染料(rhodacyanine dye)，在多种模型中具有显著的抗肿瘤活性。
MKT-077 is a rhodacyanine dye and also a heat shock protein 70 (Hsp70) inhibitor which exhibits significant antitumor activity. MKT-077 treatment (0.1 to 10 µM dose ranges) for 48 hours can effectively decrease TT cell viability. MKT-077 treatment results in accumulation of cells in the G0/G1 phase in a dose-dependent manner, and also increases sub-G0/G1 phase population in TT cell culture in a dose-dependent manner. MKT-077 also downregulates cellular levels of the proliferation marker, Ki67, and the S-phase transcription factor, E2F-1, in TT and MZ-CRC-1 cells. Moreover, flow cytometry using different doses of MKT-077 reveales that TT cells can uptake and retain MKT-077 at significantly higher levels than MZ-CRC-1 cells. MKT-077 has EC
50
values of 1.4±0.2 and 2.2±0.2 μM against MDA-MB-231 and MCF7 breast cancer cells, respectivelyl.
Systemic administration of MKT-077 significantly delays the growth of TT xenografts in mice throughout the treatment. At the end of MKT-077 treatment, it is found that tumor weights are about two-times less in MKT-077-treated group than in control group. MKT-077 treatment also results in weight loss and general toxicity in animals. Results show that the succinate-induced, ADP-stimulated respiratory rate in mitochondria isolated from the liver of rats treated with a bolus i.v. injection of 15 mg MKT-077 1kg body weight each day for 5 days is significantly lower than that of untreated controls.
MKT 077
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-15096 | MKT-077 | | 1 mg | 419元 |
| 2024/04/30 | S6718 | MKT 077
MKT-077 | 147366-41-4 | 2mg | 958.57元 |
147366-41-4, MKT 077 相关搜索:
- 生化试剂
- C21H22ClN3OS2
- MKT 077,结合MOT-2
- 化合物MKT-077
- 1-乙基-2-((Z)-((Z)-3-乙基-5-(3-甲基苯并[D]噻唑-2(3H)-亚基)-4-氧代噻唑烷-2-亚基)甲基)吡啶-1-鎓氯化物
- 147366-41-4
- MKT-077,Heat shock proteins,FJ 776,HSP,Inhibitor,inhibit,FJ776
- MKT077;MKT-077;FJ-776
- Pyridinium, 1-ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-, chloride (1:1)
- MKT-077 >=98% (HPLC), powder
- 1-Ethyl-2-((Z)-((Z)-3-ethyl-5-(3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)methyl)pyridin-1-ium chloride
- MKT-077, ≥98% (HPLC)
- 1-Ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-pyridinium chloride
- FJ 776
- MKT 077