N-单甲基-L-精氨酸单乙酸酯
| 中文名称 | N-单甲基-L-精氨酸单乙酸酯 |
|---|---|
| 中文同义词 | N-单甲基-L-精氨酸单乙酸酯;NG-单甲基-L-精氨酸乙酸盐;N蠅-MONOMETHYL-L-ARGININE ACETATE;NG-单甲基-L-精氨酸乙酸盐;NG-单甲基-L-精氨酸醋酸盐;NG-甲基-L-精氨酸醋酸盐;N5-[亚氨基(甲基氨基)甲基]-L-鸟氨酸单乙酸盐;NG—单甲基—L—精氨酸醋酸盐 100MG |
| 英文名称 | Ng-monomethyl-L-arginine acetate |
| 英文同义词 | NG-Methyl-L-arginine acetate salt >=95% (HPLC);Ngamma-methyl-L-arginine acetate;L-NMMA, NG-Monomethyl-L-arginine acetate salt, Nω-Methyl-L-arginine acetate salt, N5-(Methylamidino)-L-ornithine acetate salt;N-Monomethyl-L-arginine;Nα-Methyl-L-arginine;NG-Monomethyl-L-arginine monoacetate,99%;NG-Monomethyl-L-arginine acetate salt;L-NG-Monomethylarginine, Acetate Salt (L-NMMA) |
| CAS号 | 53308-83-1 |
| 分子式 | C7H16N4O2.C2H4O2 |
| 分子量 | 248.28 |
| EINECS号 | |
| 相关类别 | 合成;Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives;Nitric Oxide Reagents;Signalling |
| Mol文件 | 53308-83-1.mol |
| 结构式 |  |
N-单甲基-L-精氨酸单乙酸酯 性质
| 熔点 | 180-190 °C |
|---|---|
| 比旋光度 | D22 +9.5° (c = 0.10 in water) |
| 沸点 | 391.35°C (rough estimate) |
| 密度 | 1.2162 (rough estimate) |
| 折射率 | 1.6300 (estimate) |
| 储存条件 | 2-8°C |
| 溶解度 | H2O：1 mg/mL，澄清，无色 |
| 形态 | 粉末 |
| 颜色 | 白色至类白色 |
| 水溶解性 | Soluble in water (50 mM) |
| BRN | 6674255 |
| 稳定性 | -5°C储存；保持干燥 |
| InChI | 1S/C7H16N4O2.C2H4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13;1-2(3)4/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11);1H3,(H,3,4)/t5-;/m0./s1 |
| InChIKey | IKPNWIGTWUZCKM-JEDNCBNOSA-N |
| SMILES | CC(O)=O.CNC(=N)NCCC[C@H](N)C(O)=O |
Ki: 0.18 µM (nNOS), 0.4 µM (eNOS), 6 µM (iNOS)
L-NMMA, starting from 100 μM, produces a concentration-dependent inhibition of the evoked relaxations (2Hz); maximal inhibition at 1 mM averaged about 35%. The inhibitory effect of L-NMMA is unchanged by previous incubation with D-arginine while it is prevented by L-arginine (L-Arg). L-NMMA does not affect isoprenaline-induced relaxation. Superfusion of L-NMMA reduces arteriolar diameter and causes dose-dependent increases in arteriolar tone. The onset of action of L-NMMA is nearly immediate. L-NMMA inhibits vasodilator responses to the endothelium-dependent vasodilator ACh but not to the endothelium-independent NP. NE induced dose-related vasoconstriction that is significantly potentiated by L-NMMA.
安全信息
| 安全说明 | 22-24/25 |
|---|---|
| WGK Germany | 3 |
| 海关编码 | 29252900 |
| 存储类别 | 11 - 可燃固体 |
| 提供商 | 语言 |
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/09/15 | HY-18732AR | N-单甲基-L-精氨酸单乙酸酯 L-NMMA acetate (Standard) | 53308-83-1 | 1 mg | 1083元 |
| 2026/09/15 | HY-18732A | N-单甲基-L-精氨酸单乙酸酯 L-NMMA acetate | 53308-83-1 | 1 mg | 280元 |