| Company Name: |
PharmaBlock Sciences (Nanjing), Inc.
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| Tel: |
4000255188 |
| Email: |
sales@pharmablock.com |
| Products Intro: |
Product Name:methyl (1S,3R)-2-(2-chloroacetyl)-1-(4-methylsulfonylphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylate
CAS:2920221-53-8
Purity:97% Package:1G;5G;10G;100G;250G
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:GPX4-IN-4
CAS:2920221-53-8
Package:100mg/RMB 19500;25mg/RMB 11700;50mg/RMB 15300
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| Company Name: |
Cayman Chemical Company
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| Tel: |
800-364-9897 |
| Email: |
sales@caymanchem.com |
| Products Intro: |
Product Name:GPX4 24
CAS:2920221-53-8
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methyl (1S,3R)-2-(2-chloroacetyl)-1-(4-methylsulfonylphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylate manufacturers
- GPX4-IN-4
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- $2800.00 / 100mg
-
2025-08-21
- CAS:2920221-53-8
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | methyl (1S,3R)-2-(2-chloroacetyl)-1-(4-methylsulfonylphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylate Basic information |
| Product Name: | methyl (1S,3R)-2-(2-chloroacetyl)-1-(4-methylsulfonylphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylate | | Synonyms: | methyl (1S,3R)-2-(2-chloroacetyl)-1-(4-methylsulfonylphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylate;GPX4-IN-4;1H-Pyrido[3,4-b]indole-3-carboxylic acid, 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methylsulfonyl)phenyl]-, methyl ester, (1S,3R)- | | CAS: | 2920221-53-8 | | MF: | C22H21ClN2O5S | | MW: | 460.93 | | EINECS: | | | Product Categories: | | | Mol File: | 2920221-53-8.mol | ![methyl (1S,3R)-2-(2-chloroacetyl)-1-(4-methylsulfonylphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylate Structure](CAS/20240320/GIF/2920221-53-8.gif) |
| | methyl (1S,3R)-2-(2-chloroacetyl)-1-(4-methylsulfonylphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylate Chemical Properties |
| Boiling point | 702.983±60.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.414±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | solubility | DMF: 30 mg/ml
DMSO: 30 mg/ml
Ethanol: 20 mg/ml | | pka | 15.986±0.60(predicted) | | form | Solid | | color | White to off-white |
| | methyl (1S,3R)-2-(2-chloroacetyl)-1-(4-methylsulfonylphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylate Usage And Synthesis |
| Uses | GPX4-IN-4 (Compound 24) is a potent GPX4 inhibitor. GPX4-IN-4 can be used for the research of cancer[1]. | | in vivo | GPX4-IN-4 (Compound 24; 100 and 200 mg/kg; i.p.; once) engages kidney GPX4 and induces PD markers in mice[1].
GPX4-IN-4 (50 mg/kg; i.p.; daily for 20 days) has no effect on WSU-DLCL2 tumor growth in mice, although partial target engagement is observed in tumor homogenate[1]. | Animal Model: | SCID/Beige mice[1] | | Dosage: | 100 and 200 mg/kg | | Administration: | IP, once | | Result: | The GPX4 band was shifted. Engaged kidney GPX4 and induced PD markers. |
| Animal Model: | SCID/Beige mice[1] | | Dosage: | 30 and 100 mg/kg | | Administration: | IP (Pharmacokinetic Analysis) | | Result: | PK Properties of GPX4-IN-4 (Compound 24)[1]
| Dose | t1/2 (h) | Cmax (μg/mL) | AUC (μg*h/mL) | | 30 (IP) | 0.5 | 0.92 (±0.24) | 1.89 (±0.17) | | 100 (IP) | 1.7 | 5.31 (±0.53) | 16.20 (±1.70) |
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| | References | [1] Randolph JT, et al. Discovery of a Potent Chloroacetamide GPX4 Inhibitor with Bioavailability to Enable Target Engagement in Mice, a Potential Tool Compound for Inducing Ferroptosis In Vivo. J Med Chem. 2023 Mar 23;66(6):3852-3865. DOI:10.1021/acs.jmedchem.2c01415 |
| | methyl (1S,3R)-2-(2-chloroacetyl)-1-(4-methylsulfonylphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylate Preparation Products And Raw materials |
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